Journal of the Formosan Medical Association
Volume 106, Issue 11 , Pages 894-902, November 2007

Chromosomal Gain of 3q and Loss of 11q Often Associated with Nodal Metastasis in Early Stage Cervical Squamous Cell Carcinoma

  • Kuo-Feng Huang

      Affiliations

    • Departments of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Wen-Ying Lee

      Affiliations

    • Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Soon-Cen Huang

      Affiliations

    • Departments of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Yue-Shan Lin

      Affiliations

    • Departments of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Chieh-Yi Kang

      Affiliations

    • Departments of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Chiou-Ping Liou

      Affiliations

    • Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan
    • ,
  • Ching-Cherng Tzeng

      Affiliations

    • Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Ching-Cherng Tzeng, Department of Pathology, Chi Mei Medical Center, 901 Chung-Hwa Road, Yung-Kang City, Tainan 710, Taiwan

Received 27 March 2007; received in revised form 23 May 2007; accepted 3 July 2007.

Article Outline

Background/Purpose

Cervical cancer remains a health problem among women worldwide. Delineation of genetic changes is critical to understanding the molecular basis of tumor progression, as well as for identifying genetic markers for early identification of patients at high risk for a poor outcome.

Methods

To provide comparative genomic hybridization data for cervical squamous cell carcinoma in Taiwan, and to gain further insight into genetic markers associated with lymph node metastasis of this disease, we performed comparative genomic hybridization analysis of 30 consecutive cases of cervical squamous cell carcinoma (24 stage IB and 6 stage IIB).

Results

The results disclosed that higher staged tumors or those with lymph node metastasis had more chromosomal imbalances. The commonly recurrent chromosomal imbalances were gains of 3q (46.7%), 1q (36.7%) and 8q (20.0%) and losses of 11q (36.7%), 3p (33.3%), 6q (23.3%), and 2q (20.0%). The frequencies of these chromosomal imbalances in stage IB and IIB tumors did not differ significantly. However, when compared with tumors without lymph node metastasis, the loss of 11q14-q22 (5/9 vs. 3/21, p = 0.019) and gains of 3q11-q22 and 3q26-qter (6/9 vs. 5/21, p = 0.026) were significantly more prevalent in tumors with lymph node metastasis.

Conclusion

The results suggest that certain tumor-associated genes residing on 3q and 11q warrant further investigation to elucidate their role in the progression of this disease.

Key Words:  cervix , chromosomal imbalance , comparative genomic hybridization , squamous cell carcinoma

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PII: S0929-6646(08)60059-5

doi:10.1016/S0929-6646(08)60059-5

Journal of the Formosan Medical Association
Volume 106, Issue 11 , Pages 894-902, November 2007

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