Major Complications and Associated Risk Factors of Transrectal Ultrasound Guided Prostate Needle Biopsy: A Retrospective Study of 1875 Cases in Taiwan

Chiang, I-Ni; Chang, Shang-Jen; Pu, Yeong-Shiau; Huang, Kuo-How; Yu, Hong-Jen; Huang, Chao-Yuan

doi:10.1016/S0929-6646(08)60063-7

« Previous Next »Journal of the Formosan Medical Association
Volume 106, Issue 11 , Pages 929-934, November 2007

Major Complications and Associated Risk Factors of Transrectal Ultrasound Guided Prostate Needle Biopsy: A Retrospective Study of 1875 Cases in Taiwan

I-Ni Chiang
- Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei Branch, Taipei, Taiwan
Shang-Jen Chang
- Department of Urology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
Yeong-Shiau Pu
- Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei Branch, Taipei, Taiwan
Kuo-How Huang
- Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei Branch, Taipei, Taiwan
Hong-Jen Yu
- Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei Branch, Taipei, Taiwan
Chao-Yuan Huang
- Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei Branch, Taipei, Taiwan
- Correspondence to: Dr Chao-Yuan Huang, Department of Urology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan

Received 22 March 2007; received in revised form 26 June 2007; accepted 7 August 2007.

Background/Purpose

Complications from transrectal ultrasound (TRUS) guided prostate needle biopsy are occasionally encountered in the daily practice of urologists. We tried to determine the associated risk factors of patients who suffered from major complications that required hospitalization after TRUS guided prostate needle biopsies.

Methods

We did a retrospective review of 1875 TRUS guided prostate biopsies performed between January 2002 and December 2005. We defined major complications as patients with complications that needed hospitalization. We analyzed the association between biopsy complications and suspected factors, including age, prostate volume, patient's underlying disease, selection of prophylactic antibiotics, biopsy core numbers (6, 12, and 15 cores), and antiplatelet/anticoagulant usage.

Results

There were 124 patients (6.6%) with major complication. These major complications were categorized as acute prostatitis (3.8%), acute urinary retention (2.1%), hematuria (1.9%), rectal bleeding (0.2%), epididymitis (0.2%), sepsis (0.05%), and vasovagal syncope (0.05%). Patients with larger prostate size were noted to have higher risk of developing transient acute prostatitis and acute urinary retention after prostate biopsy. In contrast, age, prophylactic antibiotics (levofloxacin and pipemidic acid), underlying diseases (diabetic mellitus, hypertension, hyperlipidemia, cerebrovascular accident, coronary artery disease), increased biopsy core numbers, and antiplatelet/anticoagulant usage were not associated with major complications after prostate biopsy.