Journal of the Formosan Medical Association
Volume 107, Issue 10 , Pages 751-766, October 2008

Breast Cancer Stem Cells and Tumor Suppressor Genes

  • Wendy W. Hwang-Verslues

      Affiliations

    • Genomics Research Center, Academia Sinica, Irvine, California, USA
    • ,
  • King-Jen Chang

      Affiliations

    • Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Eva Y.-H.P. Lee

      Affiliations

    • Department of Biological Chemistry, University of California, Irvine, California, USA
    • ,
  • Wen-Hwa Lee

      Affiliations

    • Department of Biological Chemistry, University of California, Irvine, California, USA
    • Corresponding Author InformationCorrespondence to: Dr Wen-Hwa Lee, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA

Received 26 June 2008; received in revised form 9 July 2008; accepted 14 July 2008.

Article Outline

Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear. While there have been recent breakthroughs in mouse mammary stem cells and lineage determination in mammary glands, little has been determined in human cells. Microarray analyses have provided molecular categorization of breast cancer. However, the cellular origin of different types of breast cancer is largely unknown. In addition, the relationship between breast cancer stem cells and mammary progenitor cells has yet to be clarified. One of the key questions is how a normal mammary stem cell becomes a breast cancer stem cell. Importantly, the existence of different types of human breast cancers with distinct pathologic and molecular signatures suggests the possibility that different types of breast cancer stem cells may exist. Here, we aim to review the current evidence for the existence of different subtypes of breast cancer stem cells and provide further insight into how tumor suppressors might be involved in the initiation of breast cancer stem cells.

Key Words:  breast cancer , cell proliferation , progenitor cells , stem cells , tumor suppressor genes

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PII: S0929-6646(08)60188-6

doi:10.1016/S0929-6646(08)60188-6

Journal of the Formosan Medical Association
Volume 107, Issue 10 , Pages 751-766, October 2008

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