Journal of the Formosan Medical Association
Volume 107, Issue 10 , Pages 798-805 , October 2008

T2-weighted and T1-weighted Dynamic Superparamagnetic Iron Oxide (Ferucarbotran) Enhanced MRI of Hepatocellular Carcinoma and Hyperplastic Nodules

  • Ran-Chou Chen

      Affiliations

    • Department of Radiology, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • Department of Biomedical Imaging and Radiological Science, National Yang-Ming Medical University, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Ran-Chou Chen, Department of Biomedical Imaging and Radiological Science, National Yang-Ming Medical University, 155, Section 2, Linong Street, Taipei 112, Taiwan
    • ,
  • Jiunn-Ming Lii

      Affiliations

    • Department of Radiology, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Chen-Te Chou

      Affiliations

    • Department of Biomedical Imaging and Radiological Science, National Yang-Ming Medical University, Taipei, Taiwan
    • Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan
    • ,
  • Ting-An Chang

      Affiliations

    • Department of Pathology, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Wei-Tsung Chen

      Affiliations

    • Department of Radiology, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Chao-Shiang Li

      Affiliations

    • Department of Radiology, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Hsing-Yang Tu

      Affiliations

    • Department of Radiology, Taipei City Hospital Ren-Ai Branch, Taipei, Taiwan

Received 30 January 2008 ,Revised 10 April 2008 ,Accepted 15 May 2008.

References 

  1. Matsui O , Kadoya M , Kameyama T , et al.   Benign and malignant nodules in cirrhotic livers: distinction based on blood supply . Radiology . 1991;178:493–497
  2. Blakeborough A , Ward J , Wilson D , et al.   Hepatic lesion detection at MR imaging: a comparative study with four sequences . Radiology . 1997;203:756–765
  3. Kang BK , Lim JH , Kim SH , et al.   Preoperative depiction of hepatocellular carcinoma: ferumoxide-enhanced MR imaging versus triple-phase helical CT . Radiology . 2003;226:79–85
  4. Kim SH , Choi D , Kim SH , et al.   Ferucarbotran-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma . AJR Am J Roentgenol . 2005;184:1069–1076
  5. Lencioni R , Della Pina C , Bruix J , et al.   Clinical management of hepatic malignancies: ferucarbotran-enhanced magnetic resonance imaging versus contrast-enhanced spiral computed tomography . Dig Dis Sci . 2005;50:533–537
  6. Tanimoto A , Kuribayashi S . Application of superparamagnetic iron oxide to imaging of hepatocellular carcinoma . Eur J Radiol . 2006;58:200–216
  7. Tanaka M , Nakashima O , Wada Y , et al.   Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver . Hepatology . 1996;24:807–812
  8. Kawamori Y , Matsui O , Kadoya M , et al.   Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging . Radiology . 1992;183:65–72
  9. Imai Y , Murakami T , Yoshida S , et al.   Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading . Hepatology . 2000;32:205–212
  10. Reimer P , Balzer T . Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications . Eur Radiol . 2003;13:1266–1276
  11. Roncalli M . Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience . Liver Transpl . 2004;10:S9–15
  12. Kojiro M . Focus on dysplastic nodules and early hepato-cellular carcinoma: an Eastern point of view . Liver Transpl . 2004;10:S3–S8
  13. Kojiro M . Histopathology of liver cancers . Best Pract Res Clin Gastroenterol . 2005;19:39–62
  14. Hamilton SR , Aaltonen LA . Pathology and genetics of tumours of the digestive system . In: WHO Classification of Tumours . 1st edition. USA: Oxford University Press; 2001;p. 165–166
  15. Tang Y , Yamashita Y , Arakawa A , et al.   Detection of hepatocellular carcinoma arising in cirrhotic livers: comparison of gadolinium- and ferumoxides-enhanced MR imaging . AJR Am J Roentgenol . 1999;172:1547–1554
  16. Takeshita K , Nagashima I , Frui S , et al.   Effect of super-paramagnetic iron oxide-enhanced MRI of the liver with hepatocellular carcinoma and hyperpastic nodule . J Comput Assist Tomogr . 2002;26:451–455
  17. Chen RC , Wang CK , Wang CS , et al.   Depiction of vasculature in small hepatocellular carcinoma, and dysplastic nodules evaluated with carbon dioxide ultrasonography and angiography . Acta Radiologica . 2002;43:66–70
  18. Kato H , Kanematsu M , Kondo H , et al.   Ferumoxide-enhanced MR imaging of hepatocellular carcinoma: correlation with histologic tumor grade and tumor vascularity . J Magn Reson Imaging . 2004;19:76–81
  19. Li CS , Chen RC , Tu HY , et al.   Imaging well-differentiated hepatocellular carcinoma with dynamic triple-phase helical computed tomography . Br J Radiol . 2006;79:659–665
  20. Li CS , Chen RC , Jiunn-Ming Lii , et al.   Magnetic resonance imaging appearance of well-differentiated hepatocellular carcinoma . J Comput Assist Tomogr . 2006;30:597–603
  21. Zhang XH , Liang BL , Huang SQ . Correlation between SPIO-enhanced magnetic resonance imaging (MRI) and histological grading in hepatocellular carcinoma . Ai Zheng . 2003;22:734–738
  22. Tarimoto A , Yuasa Y , Shinmoto H , et al.   Superparamagnetic iron oxide-mediated hepatic signal intensity change in patients with and without cirrhosis: pulse sequence effects and Kupffer cell function . Radiology . 2002;222:661–666
  23. Macarini L , Marini S , Murrone M , et al.   Alterations in hepatic uptake and distribution of organ-specific superparamagnetic MRI contrast media: clinical findings and classification according to pathogenesis . Radiol Med (Torino) . 2004;108:92–106
  24. Stroszczynski C , Gaffke G , Gretshel S , et al.   Use of SPIO-enhanced T1- and T2-weighted images for the differentiation of liver lesion: and ROC analysis . Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr . 2003;175:1368–1375
  25. Vogl TJ , Hammerstingl R , Keck H , et al.   Differential diagnosis of focal liver lesions with MRI using the superparamagnetic contrast medium . Radiology . 1995;35:258–266
  26. Pauleit D , Textor J , Bachmann R , et al.   Hepatocellular carcinoma: detection with gadolinium- and ferumoxides-enhanced MR imaging of the liver . Radiology . 2003;222:73–80
  27. Lutz AM , Willmann JK , Goepfert K , et al.   Hepatocellular carcinoma in cirrhosis: enhancement patterns at dynamic gadolinium- and superparamagnetic iron oxide-enhanced T1-weighted MR imaging . Radiology . 2005;237:520–528

PII: S0929-6646(08)60193-X

doi: 10.1016/S0929-6646(08)60193-X

Journal of the Formosan Medical Association
Volume 107, Issue 10 , Pages 798-805 , October 2008

Article Tools