Journal of the Formosan Medical Association
Volume 107, Issue 12, Supplement , Pages S43-S51, December 2008

Statistical Tests for One-way/Two-way Translation in Translational Medicine

  • Siu-Keung Tse

      Affiliations

    • City University of Hong Kong, Hong Kong SAR, China
    • Corresponding Author InformationCorrespondence to: Associate Professor Siu-Keung Tse, Department of Management Sciences, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China
    • ,
  • Shein-Chung Chow

      Affiliations

    • Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA
    • ,
  • Chunyan Yang

      Affiliations

    • Yunnan University, Yunnan, China

Received 28 July 2008; received in revised form 25 September 2008; accepted 2 October 2008.

Article Outline

Translational medicine has been defined as bench-to-bedside research, where a basic laboratory discovery becomes applicable to the diagnosis, treatment or prevention of a specific disease, and is brought forth by either a physician/scientist who works at the interface between the research laboratory and patient care, or by a team of basic and clinical science investigators. Statistics plays an important role in translational medicine to ensure that the translational process is accurate and reliable, with statistical assurance. For this purpose, statistical criteria for assessment of one-way and two-way translation are proposed. Under a well established and validated translational model, statistical tests for one-way and two-way translation are discussed. Some discussion on lost in translation is also given.

Key Words:  lost in translation , one-way translation , predictive model , translational medicine , two-way translation

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PII: S0929-6646(09)60008-5

doi:10.1016/S0929-6646(09)60008-5

Journal of the Formosan Medical Association
Volume 107, Issue 12, Supplement , Pages S43-S51, December 2008

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