Journal of the Formosan Medical Association
Volume 107, Issue 12 , Pages 958-960, December 2008

Herpes Zoster Infection Associated with Poor Peripheral Blood Hematopoietic Stem Cell Mobilization

  • Yi-Chang Liu

      Affiliations

    • Division of Hematology-Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Po-Liang Lu

      Affiliations

    • Division of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Hui-Hua Hsiao

      Affiliations

    • Division of Hematology-Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Huei-Jen Tsai

      Affiliations

    • Division of Hematology-Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Ta-Chih Liu

      Affiliations

    • Division of Hematology-Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • ,
  • Sheng-Fung Lin

      Affiliations

    • Division of Hematology-Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Sheng-Fung Lin, Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan

Received 14 June 2007; received in revised form 20 September 2007; accepted 6 November 2007.

Article Outline

The efficacy of peripheral blood hematopoietic stem cell (PBSC) harvest is important for successful autologous transplantation. The impact of viral infection on PBSC mobilization has rarely been reported. Here, we report a patient with relapsed diffuse large B-cell lymphoma who experienced disseminated cutaneous herpes zoster infection during the neutropenic phase of PBSC mobilization. A markedly reduced number of PBSCs was initially harvested (1.72 × 106/kg, 77.2% reduction), followed by a sufficient number (7.55 × 106/kg) during remobilization with the same mobilization regimen when herpes zoster infection had subsided. Because of the temporal association, we suggest that herpes zoster infection is a risk factor for poor PBSC mobilization, and remobilization with the same regimen is feasible.

Key Words:  autologous peripheral blood stem cell transplantation , hematopoietic stem cell transplantation , herpes virus , mobilization

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PII: S0929-6646(09)60020-6

doi:10.1016/S0929-6646(09)60020-6

Journal of the Formosan Medical Association
Volume 107, Issue 12 , Pages 958-960, December 2008

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