Journal of the Formosan Medical Association
Volume 108, Issue 5 , Pages 353-366 , May 2009

The Clinical Implications of Blood Adiponectin in Cardiometabolic Disorders

  • Lin-Chau Chang

      Affiliations

    • Graduate Institute of Clinical Medicine, National Taiwan University; Taipei, Taiwan
    • ,
  • Kuo-Chin Huang

      Affiliations

    • Departments of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Yen-Wen Wu

      Affiliations

    • Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • Departments of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Hsien-Li Kao

      Affiliations

    • Department of Medicine, College of Medicine, National Taiwan University; Taipei, Taiwan
    • Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Chi-Ling Chen

      Affiliations

    • Graduate Institute of Clinical Medicine, National Taiwan University; Taipei, Taiwan
    • ,
  • Ling-Ping Lai

      Affiliations

    • Department of Medicine, College of Medicine, National Taiwan University; Taipei, Taiwan
    • Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Juey-Jen Hwang

      Affiliations

    • Department of Medicine, College of Medicine, National Taiwan University; Taipei, Taiwan
    • Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Wei-Shiung Yang

      Affiliations

    • Graduate Institute of Clinical Medicine, National Taiwan University; Taipei, Taiwan
    • Department of Medicine, College of Medicine, National Taiwan University; Taipei, Taiwan
    • Departments of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Wei-Shiung Yang, Department of Medicine, College of Medicine, National Taiwan University, 1 Chang-Teh Street, Taipei 100, Taiwan

Received 25 February 2009 ,Revised 28 February 2009 ,Accepted 2 March 2009.

References 

  1. Grundy SM . Metabolic syndrome pandemic . Arterioscler Thromb Vasc Biol . 2008;28:629–636
  2. Hampton T . Scientists study fat as endocrine organ . JAMA . 2006;296:1573–1575
  3. Ingalls AM , Dickie MM , Snell GD . Obese, a new mutation in the house mouse . J Hered . 1950;41:317–318
  4. Hummel KP , Dickie MM , Coleman DL . Diabetes, a new mutation in the mouse . Science . 1966;153:1127–1128
  5. Coleman DL . Obese and diabetes: two mutant genes causing diabetes–obesity syndromes in mice . Diabetologia . 1978;14:141–148
  6. Coleman DL . Effects of parabiosis of obese with diabetes and normal mice . Diabetologia . 1973;9:294–298
  7. Coleman DL , Hummel KP . Effects of parabiosis of normal with genetically diabetic mice . Am J Physiol . 1969;217:1298–1304
  8. Zhang Y , Proenca R , Maffei M , et al.   Positional cloning of the mouse obese gene and its human homologue . Nature . 1994;372:425–432
  9. Halaas JL , Gajiwala KS , Maffei M , et al.   Weight-reducing effects of the plasma protein encoded by the obese gene . Science . 1995;269:543–546
  10. Tartaglia LA , Dembski M , Weng X , et al.   Identification and expression cloning of a leptin receptor, ob-r . Cell . 1995;83:1263–1271
  11. Myers MG , Cowley MA , Munzberg H . Mechanisms of leptin action and leptin resistance . Annu Rev Physiol . 2008;70:537–556
  12. Leinninger GM , Myers MG . Lrb signals act within a distributed network of leptin-responsive neurones to mediate leptin action . Acta Physiol (Oxf) . 2008;192:49–59
  13. Lu JY , Huang KC , Chang LC , et al.   Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond . J Biomed Sci . 2008;15:565–576
  14. Scherer PE , Williams S , Fogliano M , et al.   A novel serum protein similar to c1q, produced exclusively in adipocytes . J Biol Chem . 1995;270:26746–26749
  15. Maeda K , Okubo K , Shimomura I , et al.   Cdna cloning and expression of a novel adipose specific collagen-like factor, apm1 (adipose most abundant gene transcript 1) . Biochem Biophys Res Commun . 1996;221:286–289
  16. Hu E , Liang P , Spiegelman BM . Adipoq is a novel adipose-specific gene dysregulated in obesity . J Biol Chem . 1996;271:10697–10703
  17. Nakano Y , Tobe T , Choi-Miura NH , et al.   Isolation and characterization of gbp28, a novel gelatin-binding protein purified from human plasma . J Biochem (Tokyo) . 1996;120:803–812
  18. Pajvani UB , Du X , Combs TP , et al.   Structure–function studies of the adipocyte-secreted hormone acrp30/adiponectin. Implications for metabolic regulation and bioactivity . J Biol Chem . 2003;278:9073–9085
  19. Magkos F , Sidossis LS . Recent advances in the measurement of adiponectin isoform distribution . Curr Opin Clin Nutr Metab Care . 2007;10:571–575
  20. Waki H , Yamauchi T , Kamon J , et al.   Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin . J Biol Chem . 2003;278:40352–40363
  21. Kobayashi H , Ouchi N , Kihara S , et al.   Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin . Circ Res . 2004;94:e27–e31
  22. Pajvani UB , Hawkins M , Combs TP , et al.   Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity . J Biol Chem . 2004;279:12152–12162
  23. Fruebis J , Tsao TS , Javorschi S , et al.   Proteolytic cleavage product of 30-kda adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice . Proc Natl Acad Sci USA . 2001;98:2005–2010
  24. Berg AH , Combs TP , Du X , et al.   The adipocyte-secreted protein acrp30 enhances hepatic insulin action . Nat Med . 2001;7:947–953
  25. Yamauchi T , Kamon J , Waki H , et al.   The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity . Nat Med . 2001;7:941–946
  26. Combs TP , Berg AH , Obici S , et al.   Endogenous glucose production is inhibited by the adipose-derived protein acrp30 . J Clin Invest . 2001;108:1875–1881
  27. Kubota N , Terauchi Y , Yamauchi T , et al.   Disruption of adiponectin causes insulin resistance and neointimal formation . J Biol Chem . 2002;277:25863–25866
  28. Maeda N , Shimomura I , Kishida K , et al.   Diet-induced insulin resistance in mice lacking adiponectin/acrp30 . Nat Med . 2002;8:731–737
  29. Yamauchi T , Kamon J , Waki H , et al.   Globular adiponectin protected ob/ob mice from diabetes and apoE-deficient mice from atherosclerosis . J Biol Chem . 2003;278:2461–2468
  30. Ohashi K , Kihara S , Ouchi N , et al.   Adiponectin replenishment ameliorates obesity-related hypertension . Hypertension . 2006;47:1108–1116
  31. Shibata R , Ouchi N , Ito M , et al.   Adiponectin-mediated modulation of hypertrophic signals in the heart . Nat Med . 2004;10:1384–1389
  32. Okamoto Y , Kihara S , Ouchi N , et al.   Adiponectin reduces atherosclerosis in apolipoprotein e-deficient mice . Circulation . 2002;106:2767–2770
  33. Matsuda M , Shimomura I , Sata M , et al.   Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis . J Biol Chem . 2002;277:37487–37491
  34. Kato H , Kashiwagi H , Shiraga M , et al.   Adiponectin acts as an endogenous antithrombotic factor . Arterioscler Thromb Vasc Biol . 2006;26:224–230
  35. Shibata R , Ouchi N , Kihara S , et al.   Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling . J Biol Chem . 2004;279:28670–28674
  36. Yamauchi T , Kamon J , Ito Y , et al.   Cloning of adiponectin receptors that mediate antidiabetic metabolic effects . Nature . 2003;423:762–769
  37. Yamauchi T , Nio Y , Maki T , et al.   Targeted disruption of adipor1 and adipor2 causes abrogation of adiponectin binding and metabolic actions . Nat Med . 2007;13:332–339
  38. Luo XH , Guo LJ , Yuan LQ , et al.   Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway . Exp Cell Res . 2005;309:99–109
  39. Wu X , Mahadev K , Fuchsel L , et al.   Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of camp and amp kinase signaling . Am J Physiol Endocrinol Metab . 2007;293:E1836–E1844
  40. Chen H , Montagnani M , Funahashi T , et al.   Adiponectin stimulates production of nitric oxide in vascular endothelial cells . J Biol Chem . 2003;278:45021–45026
  41. Kadowaki T , Yamauchi T , Kubota N . The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS . FEBS Lett . 2008;582:74–80
  42. Arita Y , Kihara S , Ouchi N , et al.   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity . Biochem Biophys Res Commun . 1999;257:79–83
  43. Ebinuma H , Miyazaki O , Yago H , et al.   A novel ELISA system for selective measurement of human adiponectin multimers by using proteases . Clin Chim Acta . 2006;372:47–53
  44. Nakano Y , Tajima S , Yoshimi A , et al.   A novel enzyme-linked immunosorbent assay specific for high-molecular-weight adiponectin . J Lipid Res . 2006;47:1572–1582
  45. Ebinuma H , Miida T , Yamauchi T , et al.   Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid . Clin Chem . 2007;53:1541–1544
  46. Tanita T , Miyakoshi H , Nakano Y . Performance of ELISA for specific measurement of high-molecular-weight (HMW) adiponectin . J Immunol Methods . 2008;333:139–146
  47. Sinha MK , Songer T , Xiao Q , et al.   Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA . Clin Chem . 2007;53:2144–2151
  48. Glintborg D , Frystyk J , Hojlund K , et al.   Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome . Clin Endocrinol (Oxf) . 2008;68:165–174
  49. Rogers CQ , Ajmo JM , You M . Adiponectin and alcoholic fatty liver disease . IUBMB Life . 2008;60:790–797
  50. Gualillo O , Gonzalez-Juanatey JR , Lago F . The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives . Trends Cardiovasc Med . 2007;17:275–283
  51. Kelesidis I , Kelesidis T , Mantzoros CS . Adiponectin and cancer: a systematic review . Br J Cancer . 2006;94:1221–1225
  52. Yang WS , Chuang LM . Human genetics of adiponectin in the metabolic syndrome . J Mol Med . 2006;84:112–121
  53. Menzaghi C , Trischitta V , Doria A . Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease . Diabetes . 2007;56:1198–1209
  54. Crimmins NA , Woo JG , Kaushal RD , et al.   Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans . Obesity . 2007;15:1903–1907
  55. Cnop M , Havel PJ , Utzschneider KM , et al.   Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex . Diabetologia . 2003;46:459–469
  56. Yatagai T , Nagasaka S , Taniguchi A , et al.   Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus . Metabolism . 2003;52:1274–1278
  57. Staiger H , Tschritter O , Machann J , et al.   Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans . Obes Res . 2003;11:368–372
  58. Vozarova B , Stefan N , Lindsay RS , et al.   Low plasma adiponectin concentrations do not predict weight gain in humans . Diabetes . 2002;51:2964–2967
  59. Hotta K , Funahashi T , Arita Y , et al.   Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients . Arterioscler Thromb Vasc Biol . 2000;20:1595–1599
  60. Hulver MW , Zheng D , Tanner CJ , et al.   Adiponectin is not altered with exercise training despite enhanced insulin action . Am J Physiol Endocrinol Metab . 2002;283:E861–E865
  61. Yatagai T , Nishida Y , Nagasaka S , et al.   Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men . Endocr J . 2003;50:233–238
  62. Valsamakis G , McTernan PG , Chetty R , et al.   Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines . Metabolism . 2004;53:430–434
  63. Hsieh CJ , Wang PW , Liu RT , et al.   Orlistat for obesity: benefits beyond weight loss . Diabetes Res Clin Pract . 2005;67:78–83
  64. Kim DM , Yoon SJ , Ahn CW , et al.   Sibutramine improves fat distribution and insulin resistance, and increases serum adiponectin levels in Korean obese nondiabetic premenopausal women . Diabetes Res Clin Pract . 2004;66(Suppl 1):S139–S144
  65. Hung YJ , Chen YC , Pei D , et al.   Sibutramine improves insulin sensitivity without alteration of serum adiponectin in obese subjects with type 2 diabetes . Diabet Med . 2005;22:1024–1030
  66. Despres JP , Golay A , Sjostrom L . Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia . N Engl J Med . 2005;353:2121–2134
  67. Calvani M , Scarfone A , Granato L , et al.   Restoration of adiponectin pulsatility in severely obese subjects after weight loss . Diabetes . 2004;53:939–947
  68. Yang WS , Lee WJ , Funahashi T , et al.   Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin . J Clin Endocrinol Metab . 2001;86:3815–3819
  69. Klein S , Fontana L , Young VL , et al.   Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease . N Engl J Med . 2004;350:2549–2557
  70. Giugliano G , Nicoletti G , Grella E , et al.   Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women . Br J Plast Surg . 2004;57:190–194
  71. Nakatani H , Hirose H , Yamamoto Y , et al.   Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents . Metabolism . 2008;57:157–162
  72. Kaser S , Tatarczyk T , Stadlmayr A , et al.   Effect of obesity and insulin sensitivity on adiponectin isoform distribution . Eur J Clin Invest . 2008;38:827–834
  73. Schober F , Neumeier M , Weigert J , et al.   Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release . Biochem Biophys Res Commun . 2007;361:968–973
  74. Bobbert T , Rochlitz H , Wegewitz U , et al.   Changes of adiponectin oligomer composition by moderate weight reduction . Diabetes . 2005;54:2712–2719
  75. Engl J , Bobbert T , Ciardi C , et al.   Effects of pronounced weight loss on adiponectin oligomer composition and metabolic parameters . Obesity (Silver Spring) . 2007;15:1172–1178
  76. Weyer C , Funahashi T , Tanaka S , et al.   Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia . J Clin Endocrinol Metab . 2001;86:1930–1935
  77. Yang WS , Lee WJ , Funahashi T , et al.   Plasma adiponectin levels in overweight and obese Asians . Obes Res . 2002;10:1104–1110
  78. Lindsay RS , Funahashi T , Hanson RL , et al.   Adiponectin and development of type 2 diabetes in the Pima Indian population . Lancet . 2002;360:57–58
  79. Daimon M , Oizumi T , Saitoh T , et al.   Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population: the Funagata study . Diabetes Care . 2003;26:2015–2020
  80. Snehalatha C , Mukesh B , Simon M , et al.   Plasma adiponectin is an independent predictor of type 2 diabetes in Asian Indians . Diabetes Care . 2003;26:3226–3229
  81. Stefan N , Vozarova B , Funahashi T , et al.   Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans . Diabetes . 2002;51:1884–1888
  82. Yamamoto Y , Hirose H , Saito I , et al.   Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population . J Clin Endocrinol Metab . 2004;89:87–90
  83. Duncan BB , Schmidt MI , Pankow JS , et al.   Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study . Diabetes . 2004;53:2473–2478
  84. Snijder MB , Heine RJ , Seidell JC , et al.   Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the Hoorn study . Diabetes Care . 2006;29:2498–2503
  85. Mather KJ , Funahashi T , Matsuzawa Y , et al.   Adiponectin, change in adiponectin, and progression to diabetes in the diabetes prevention program . Diabetes . 2008;57:980–986
  86. Hara K , Horikoshi M , Yamauchi T , et al.   Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome . Diabetes Care . 2006;29:1357–1362
  87. Nakashima R , Kamei N , Yamane K , et al.   Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans . J Clin Endocrinol Metab . 2006;91:3873–3877
  88. Basu R , Pajvani UB , Rizza RA , et al.   Selective downregulation of the high-molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes. Differential regulation from nondiabetic subjects . Diabetes . 2007;56:2174–2177
  89. Seino Y , Hirose H , Saito I , et al.   High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men . Metabolism . 2007;56:1493–1499
  90. Imagawa A , Funahashi T , Nakamura T , et al.   Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes . Diabetes Care . 2002;25:1665–1666
  91. Celi F , Bini V , Papi F , et al.   Circulating adipocytokines in non-diabetic and type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development . Diabet Med . 2006;23:660–665
  92. Frystyk J , Tarnow L , Hansen TK , et al.   Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications . Diabetologia . 2005;48:1911–1918
  93. Galler A , Gelbrich G , Kratzsch J , et al.   Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study . Eur J Endocrinol . 2007;157:481–489
  94. Leth H , Andersen KK , Frystyk J , et al.   Elevated levels of high-molecular-weight adiponectin in type 1 diabetes . J Clin Endocrinol Metab . 2008;93:3186–3191
  95. Truyen I , De Grijse J , Van Schravendijk C , et al.   Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives . Diabetologia . 2007;50:2143–2146
  96. Schaffler A , Herfarth H , Paul G , et al.   Identification of influencing variables on adiponectin serum levels in diabetes mellitus type 1 and type 2 . Exp Clin Endocrinol Diabetes . 2004;112:383–389
  97. Schalkwijk CG , Chaturvedi N , Schram MT , et al.   Adiponectin is inversely associated with renal function in type 1 diabetic patients . J Clin Endocrinol Metab . 2006;91:129–135
  98. Saraheimo M , Forsblom C , Thorn L , et al.   Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes . Diabetes Care . 2008;31:1165–1169
  99. Barnes MM , Curran-Everett D , Hamman RF , et al.   Determinants of adiponectin levels in young people with type 1 diabetes . Diabet Med . 2008;25:365–369
  100. Balagopal P , George D , Yarandi H , et al.   Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents . J Clin Endocrinol Metab . 2005;90:6192–6197
  101. Yang WS , Jeng CY , Wu TJ , et al.   Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients . Diabetes Care . 2002;25:376–380
  102. Putz DM , Goldner WS , Bar RS , et al.   Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy . Metabolism . 2004;53:1454–1461
  103. Nagasaka S , Taniguchi A , Aiso Y , et al.   Effect of glimepiride on serum adiponectin level in subjects with type 2 diabetes . Diabetes Care . 2003;26:2215–2216
  104. Tsunekawa T , Hayashi T , Suzuki Y , et al.   Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects . Diabetes Care . 2003;26:285–289
  105. Muller G . The molecular mechanism of the insulinmimetic/sensitizing activity of the antidiabetic sulfonylurea drug amaryl . Mol Med . 2000;6:907–933
  106. Lund SS , Tarnow L , Stehouwer CD , et al.   Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial . Diabetes Obes Metab . 2007;9:394–407
  107. Spranger J , Mohlig M , Wegewitz U , et al.   Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome . Clin Endocrinol (Oxf) . 2004;61:738–746
  108. Rasouli N , Yao-Borengasser A , Miles LM , et al.   Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression . Am J Physiol Endocrinol Metab . 2006;290:E42–E46
  109. Ochiai H , Ooka H , Shida C , et al.   Acarbose treatment increases serum total adiponectin levels in patients with type 2 diabetes . Endocr J . 2008;55:549–556
  110. Hirose H , Kawai T , Yamamoto Y , et al.   Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes . Metabolism . 2002;51:314–317
  111. Qurashi S , Mynarcik DC , McNurlan MA , et al.   Importance of the high-molecular-mass isoform of adiponectin in improved insulin sensitivity with rosiglitazone treatment in HIV disease . Clin Sci (Lond) . 2008;115:197–202
  112. Tonelli J , Li W , Kishore P , et al.   Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes . Diabetes . 2004;53:1621–1629
  113. Pfutzner A , Lorra B , Abdollahnia MR , et al.   The switch from sulfonylurea to preprandial short-acting insulin analog substitution has an immediate and comprehensive beta-cell protective effect in patients with type 2 diabetes mellitus . Diabetes Technol Ther . 2006;8:375–384
  114. Miyashita Y , Nishimura R , Nemoto M , et al.   Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure . Cardiovasc Diabetol . 2008;7:16
  115. Juurinen L , Tiikkainen M , Hakkinen AM , et al.   Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes . Am J Physiol Endocrinol Metab . 2007;292:E829–E835
  116. Mohlig M , Wegewitz U , Osterhoff M , et al.   Insulin decreases human adiponectin plasma levels . Horm Metab Res . 2002;34:655–658
  117. Dullaart RP , Riemens SC , Meinardi JR , et al.   Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by acipimox . Scand J Clin Lab Invest . 2005;65:523–531
  118. Brame LA , Considine RV , Yamauchi M , et al.   Insulin and endothelin in the acute regulation of adiponectin in vivo in humans . Obes Res . 2005;13:582–588
  119. Blumer RM , van der Crabben SN , Stegenga ME , et al.   Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans . Am J Physiol Endocrinol Metab . 2008;295:E613–E617
  120. Krusinova E , Klementova M , Kopecky J , et al.   Effect of acute hyperinsulinaemia with and without angiotensin II type 1 receptor blockade on resistin and adiponectin concentrations and expressions in healthy subjects . Eur J Endocrinol . 2007;157:443–449
  121. Matsubara M , Maruoka S , Katayose S . Decreased plasma adiponectin concentrations in women with dyslipidemia . J Clin Endocrinol Metab . 2002;87:2764–2769
  122. Huang KC , Lue BH , Yen RF , et al.   Plasma adiponectin levels and metabolic factors in nondiabetic adolescents . Obes Res . 2004;12:119–124
  123. Schulze MB , Rimm EB , Shai I , et al.   Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes . Diabetes Care . 2004;27:1680–1687
  124. Kazumi T , Kawaguchi A , Hirano T , et al.   Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men . Metabolism . 2004;53:589–593
  125. Lara-Castro C , Luo N , Wallace P , et al.   Adiponectin multimeric complexes and the metabolic syndrome trait cluster . Diabetes . 2006;55:249–259
  126. Koh KK , Quon MJ , Han SH , et al.   Additive beneficial effects of losartan combined with simvastatin in the treatment of hypercholesterolemic, hypertensive patients . Circulation . 2004;110:3687–3692
  127. Bayes B , Granada ML , Lauzurica R , et al.   Effect of low doses of atorvastatin on adiponectin, glucose homeostasis, and clinical inflammatory markers in kidney transplant recipients . Transplant Proc . 2005;37:3808–3812
  128. Gannage-Yared MH , Azar RR , Amm-Azar M , et al.   Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients . Metabolism . 2005;54:947–951
  129. Sonmez A , Dogru T , Tasci I , et al.   The effect of fluvastatin on plasma adiponectin levels in dyslipidaemia . Clin Endocrinol (Oxf) . 2006;64:567–572
  130. Gouni-Berthold I , Berthold HK , Chamberland JP , et al.   Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men . Clin Endocrinol (Oxf) . 2008;68:536–541
  131. Koh KK , Quon MJ , Han SH , et al.   Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients . Diabetes Care . 2006;29:195–201
  132. Rosenson RS . Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients . Obesity (Silver Spring) . 2009;17:504–509
  133. Asano A , Kobayashi J , Murase Y , et al.   Effects of fenofibrate therapy on plasma ubiquinol-10 and ubiquinone-10 levels in Japanese patients with hyperlipidemia and type 2 diabetes mellitus . Pharmacotherapy . 2006;26:447–451
  134. Otto C , Otto B , Frost RJ , et al.   Short-term therapy with atorvastatin or fenofibrate does not affect plasma ghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixed hyperlipoproteinaemia . Acta Diabetol . 2007;44:65–68
  135. Oki K , Koide J , Nakanishi S , et al.   Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia . Endocr J . 2007;54:431–435
  136. Westphal S , Borucki K , Taneva E , et al.   Extended-release niacin raises adiponectin and leptin . Atherosclerosis . 2007;193:361–365
  137. Plaisance EP , Grandjean PW , Brunson BL , et al.   Increased total and high-molecular weight adiponectin after extended-release niacin . Metabolism . 2008;57:404–409
  138. Westphal S , Luley C . Preferential increase in high-molecular weight adiponectin after niacin . Atherosclerosis . 2008;198:179–183
  139. Bajaj M , Suraamornkul S , Kashyap S , et al.   Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes . J Clin Endocrinol Metab . 2004;89:4649–4655
  140. Bajaj M , Suraamornkul S , Romanelli A , et al.   Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients . Diabetes . 2005;54:3148–3153
  141. Bernstein EL , Koutkia P , Ljungquist K , et al.   Acute regulation of adiponectin by free fatty acids . Metabolism . 2004;53:790–793
  142. Kazumi T , Kawaguchi A , Sakai K , et al.   Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure . Diabetes Care . 2002;25:971–976
  143. Dzielinska Z , Januszewicz A , Wiecek A , et al.   Decreased plasma concentration of a novel anti-inflammatory protein–adiponectin–in hypertensive men with coronary artery disease . Thromb Res . 2003;110:365–369
  144. Huang KC , Chen CL , Chuang LM , et al.   Plasma adiponectin levels and blood pressures in nondiabetic adolescent females . J Clin Endocrinol Metab . 2003;88:4130–4134
  145. Adamczak M , Wiecek A , Funahashi T , et al.   Decreased plasma adiponectin concentration in patients with essential hypertension . Am J Hypertens . 2003;16:72–75
  146. Chow WS , Cheung BM , Tso AW , et al.   Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study . Hypertension . 2007;49:1455–1461
  147. Koh KK , Quon MJ , Han SH , et al.   Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs . Int J Cardiol . 2008 Dec 5; [Epub ahead of print]
  148. Piecha G , Adamczak M , Chudek J , et al.   Indapamide decreases plasma adiponectin concentration in patients with essential hypertension . Kidney Blood Press Res . 2007;30:187–194
  149. Yilmaz MI , Sonmez A , Caglar K , et al.   Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome . Nephrology (Carlton) . 2007;12:147–153
  150. Benndorf RA , Rudolph T , Appel D , et al.   Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension . Metabolism . 2006;55:1159–1164
  151. Koh KK , Han SH , Ahn JY , et al.   Amlodipine improves endothelial function and metabolic parameters in patients with hypertension . Int J Cardiol . 2009;133:23–31
  152. Furuhashi M , Ura N , Higashiura K , et al.   Blockade of the renin–angiotensin system increases adiponectin concentrations in patients with essential hypertension . Hypertension . 2003;42:76–81
  153. Koh KK , Quon MJ , Han SH , et al.   Anti-inflammatory and metabolic effects of candesartan in hypertensive patients . Int J Cardiol . 2006;108:96–100
  154. Delles C , Raff U , Mimran A , et al.   Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes . Am J Hypertens . 2008;21:1330–1336
  155. Matsumoto S , Takebayashi K , Aso Y . The effect of spironolactone on circulating adipocytokines in patients with type 2 diabetes mellitus complicated by diabetic nephropathy . Metabolism . 2006;55:1645–1652
  156. Uchida T , Shimizu M , Sakai Y , et al.   Effects of losartan on serum total and high-molecular weight adiponectin concentrations in hypertensive patients with metabolic syndrome . Metabolism . 2008;57:1278–1285
  157. Ouchi N , Kihara S , Arita Y , et al.   Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin . Circulation . 1999;100:2473–2476
  158. Kumada M , Kihara S , Sumitsuji S , et al.   Association of hypoadiponectinemia with coronary artery disease in men . Arterioscler Thromb Vasc Biol . 2003;23:85–89
  159. Nakamura Y , Shimada K , Fukuda D , et al.   Implications of plasma concentrations of adiponectin in patients with coronary artery disease . Heart . 2004;90:528–533
  160. Pilz S , Maerz W , Weihrauch G , et al.   Adiponectin serum concentrations in men with coronary artery disease: the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study . Clin Chim Acta . 2006;364:251–255
  161. Lu G , Chiem A , Anuurad E , et al.   Adiponectin levels are associated with coronary artery disease across Caucasian and African-American ethnicity . Transl Res . 2007;149:317–323
  162. Costacou T , Zgibor JC , Evans RW , et al.   The prospective association between adiponectin and coronary artery disease among individuals with type 1 diabetes. The Pittsburgh epidemiology of diabetes complications study . Diabetologia . 2005;48:41–48
  163. Schnabel R , Messow CM , Lubos E , et al.   Association of adiponectin with adverse outcome in coronary artery disease patients: results from the atherogene study . Eur Heart J . 2008;29:649–657
  164. Takemoto F , Katori H , Sawa N , et al.   Plasma adiponectin: a predictor of coronary heart disease in hemodialysis patients–a Japanese prospective eight-year study . Nephron Clin Pract . 2008;111:c12–c20
  165. Lim S , Koo BK , Cho SW , et al.   Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: the Korean Atherosclerosis Study (KAS): a 42-month prospective study . Atherosclerosis . 2008;196:398–404
  166. Cavusoglu E , Ruwende C , Chopra V , et al.   Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain . Eur Heart J . 2006;27:2300–2309
  167. Pischon T , Girman CJ , Hotamisligil GS , et al.   Plasma adiponectin levels and risk of myocardial infarction in men . JAMA . 2004;291:1730–1737
  168. Lawlor DA , Davey Smith G , Ebrahim S , et al.   Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women . J Clin Endocrinol Metab . 2005;90:5677–5683
  169. Soderberg S , Colquhoun D , Keech A , et al.   Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the lipid study . Int J Obes (Lond) . 2009;33:123–130
  170. Sattar N , Wannamethee G , Sarwar N , et al.   Adiponectin and coronary heart disease: a prospective study and metaanalysis . Circulation . 2006;114:623–629
  171. Aso Y , Yamamoto R , Wakabayashi S , et al.   Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin . Diabetes . 2006;55:1954–1960
  172. Inoue T , Kotooka N , Morooka T , et al.   High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease . Am J Cardiol . 2007;100:569–574
  173. von Eynatten M , Humpert PM , Bluemm A , et al.   Highmolecular weight adiponectin is independently associated with the extent of coronary artery disease in men . Atherosclerosis . 2008;199:123–128
  174. Rizza S , Clementi F , Porzio O , et al.   Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD . Nutr Metab Cardiovasc Dis . 2009;19:54–60
  175. von Eynatten M , Hamann A , Twardella D , et al.   Atherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease . Eur Heart J . 2008;29:1307–1315
  176. Sattar N , Watt P , Cherry L , et al.   High molecular weight adiponectin is not associated with incident coronary heart disease in older women: a nested prospective case-control study . J Clin Endocrinol Metab . 2008;93:1846–1849
  177. Hwang JJ , Yang WS , Chiang FT , et al.   Association of circulating matrix metalloproteinase-1, but not adiponectin, with advanced coronary artery disease . Atherosclerosis . 2008 Aug 28; [Epub ahead of print]
  178. Chen MP , Tsai JC , Chung FM , et al.   Hypoadiponectinemia is associated with ischemic cerebrovascular disease . Arterioscler Thromb Vasc Biol . 2005;25:821–826
  179. Efstathiou SP , Tsioulos DI , Tsiakou AG , et al.   Plasma adiponectin levels and five-year survival after first-ever ischemic stroke . Stroke . 2005;36:1915–1919
  180. Soderberg S , Stegmayr B , Stenlund H , et al.   Leptin, but not adiponectin, predicts stroke in males . J Intern Med . 2004;256:128–136
  181. Matsumoto M , Ishikawa S , Kajii E . Association of adiponectin with cerebrovascular disease: a nested case-control study . Stroke . 2008;39:323–328
  182. Stott DJ , Welsh P , Rumley A , et al.   Adipocytokines and risk of stroke in older people: a nested case-control study . Int J Epidemiol . 2009;38:253–261
  183. Lim PS , Hu CY , Wu MY , et al.   Plasma adiponectin is associated with ankle-brachial index in patients on haemodialysis . Nephrology (Carlton) . 2007;12:546–552
  184. Kokubu N , Tsuchihashi K , Yuda S , et al.   Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2a receptor antagonist, in patients with peripheral arterial disease . Circ J . 2006;70:1451–1456
  185. Kistorp C , Faber J , Galatius S , et al.   Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure . Circulation . 2005;112:1756–1762
  186. George J , Patal S , Wexler D , et al.   Circulating adiponectin concentrations in patients with congestive heart failure . Heart . 2006;92:1420–1424
  187. Wannamethee SG , Whincup PH , Lennon L , et al.   Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure . Arch Intern Med . 2007;167:1510–1517
  188. Tamura T , Furukawa Y , Taniguchi R , et al.   Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure . Circ J . 2007;71:623–630
  189. Haugen E , Furukawa Y , Isic A , et al.   Increased adiponectin level in parallel with increased NT-pro BNP in patients with severe heart failure in the elderly: a hospital cohort study . Int J Cardiol . 2008;125:216–219
  190. Norrelund H , Wiggers H , Halbirk M , et al.   Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure . J Intern Med . 2006;260:11–21
  191. McEntegart MB , Awede B , Petrie MC , et al.   Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and b-type natriuretic peptide . Eur Heart J . 2007;28:829–835
  192. Ingelsson E , Riserus U , Berne C , et al.   Adiponectin and risk of congestive heart failure . JAMA . 2006;295:1772–1774
  193. Tsutamoto T , Tanaka T , Sakai H , et al.   Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure . Eur Heart J . 2007;28:1723–1730
  194. Komaba H , Igaki N , Goto S , et al.   Adiponectin is associated with brain natriuretic peptide and left ventricular hypertrophy in hemodialysis patients with type 2 diabetes mellitus . Nephron Clin Pract . 2007;107:c103–c108
  195. von Eynatten M , Hamann A , Twardella D , et al.   Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease . Clin Chem . 2006;52:853–859
  196. Tanaka T , Tsutamoto T , Sakai H , et al.   Effect of atrial natriuretic peptide on adiponectin in patients with heart failure . Eur J Heart Fail . 2008;10:360–366
  197. Shimano M , Shibata R , Tsuji Y , et al.   Circulating adiponectin levels in patients with atrial fibrillation . Circ J . 2008;72:1120–1124

PII: S0929-6646(09)60079-6

doi: 10.1016/S0929-6646(09)60079-6

Journal of the Formosan Medical Association
Volume 108, Issue 5 , Pages 353-366 , May 2009

Article Tools