Journal of the Formosan Medical Association
Volume 108, Issue 5 , Pages 428-432, May 2009

Human Papillomavirus Type and Clinical Manifestation in Seven Cases of Large-cell Neuroendocrine Cervical Carcinoma

  • Kung-Liahng Wang

      Affiliations

    • Department of Obstetrics and Gynecology, Taiwan
    • Department of National Taipei College of Nursing, Taiwan
    • Department of Mackay Medicine, Nursing and Management College, Taiwan
    • ,
  • Tao-Yeuan Wang

      Affiliations

    • Department of Pathology, Taiwan
    • ,
  • Yu-Chuen Huang

      Affiliations

    • Department of Medical Research, Mackay Memorial Hospital, Taiwan
    • Department of Medical Research, China Medical University Hospital, Taiwan
    • Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    • ,
  • Jerry Cheng-Yen Lai

      Affiliations

    • Department of Medical Research, Mackay Memorial Hospital, Taiwan
    • ,
  • Ting-Chang Chang

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University Medical School, Taiwan
    • ,
  • Ming-Shyen Yen

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Ming-Shyen Yen, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan

Received 2 December 2008; received in revised form 16 December 2008; accepted 22 December 2008.

Article Outline

Large-cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a very rare malignancy. We aimed to investigate the role of human papillomavirus (HPV) on the survival of patients, and its correlation with clinical parameters of HPV status or survival outcomes. Only seven cases of LCNEC were retrospectively collected among 8018 (0.087%) invasive cervical carcinomas from the cancer registry systems at Mackay Memorial Hospital and Veterans General Hospital over a period of 17 years. The median survival time was 17.2 months, including only one long-term survivor (> 5 years). The 2-year and 5-year survival rates after diagnosis were 42% and 30%, respectively. The results indicated that the majority of LCNEC cases were dominated by high-risk HPV-18. No clinical parameters appeared to be associated with HPV-18 or survival outcomes of LCNEC patients. Pelvic lymph node metastasis positivity could also be considered as a prognostic factor for this disease.

Key Words:  cervical carcinoma , HPV , large cell neuroendocrine carcinoma

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PII: S0929-6646(09)60088-7

doi:10.1016/S0929-6646(09)60088-7

Journal of the Formosan Medical Association
Volume 108, Issue 5 , Pages 428-432, May 2009

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