Journal of the Formosan Medical Association
Volume 105, Issue 11 , Pages 918-925, 2006

Factors Affecting Patient-controlled Analgesia Requirements

  • Kuang-Yi Chang

      Affiliations

    • Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
    • National Yang-Ming University School of Medicine, Taipei, Taiwan
    • Biostatistics Laboratory, College of Public Health, National Taiwan University, Taipei, Taiwan
    • ,
  • Mei-Yung Tsou

      Affiliations

    • Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
    • National Yang-Ming University School of Medicine, Taipei, Taiwan
    • ,
  • Kwok-Hon Chan

      Affiliations

    • Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
    • National Yang-Ming University School of Medicine, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Kwok-Hon Chan, Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, 201, Section 2, Shih-Pai Road, Peitou 112, Taipei, Taiwan
    • ,
  • Chun-Sung Sung

      Affiliations

    • Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
    • National Yang-Ming University School of Medicine, Taipei, Taiwan
    • ,
  • Wen-Kuei Chang

      Affiliations

    • Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
    • National Yang-Ming University School of Medicine, Taipei, Taiwan

Received 8 November 2005; received in revised form 30 December 2005; accepted 4 April 2006.

Article Outline

Background/Purpose

Intravenous patient-controlled analgesia (IVPCA) is one of the most widely used postoperative analgesic methods. Many factors could affect the total analgesic consumption of IVPCA. This retrospective study investigated the relationship between patient characteristics and total morphine consumption during a 3-day course of postoperative IVPCA.

Methods

Patients receiving surgery under general anesthesia with postoperative IVPCA for 3 days during the period between January 2002 and December 2003 were included. Patient data including age, sex, weight, height, body mass index (BMI), operation type and site were collected. Total morphine consumption was recorded at the end of the 3-day IVPCA course. Stepwise regression analyses were conducted to select factors significantly associated with morphine consumption. Stratified analyses were also conducted among different surgical, BMI and age subgroups.

Results

A total of 1308 patients (646 men, 662 women) were included in the analysis. For all operations, weight, age, procedures involving malignant disease, and surgical sites were significantly associated with total morphine consumption. The R and adjusted R2 values of the selected model were 0.509 and 0.256, respectively. Weight was the only common factor among all stratified analyses (all p <0.001). Age was negatively correlated with morphine consumption. Gender was not a significant factor except in lower abdominal operations. Height was not associated with total morphine consumption. BMI status was not significantly associated with components of the selected factors.

Conclusion

This study demonstrated that weight and surgical sites significantly influence total IVPCA requirements. The effect of surgical sites should be considered when evaluating the influence of demographic characteristics on IVPCA demand.

Key Words:  body mass index , general anesthesia , morphine , patient-controlled analgesia

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PII: S0929-6646(09)60177-7

doi:10.1016/S0929-6646(09)60177-7

Journal of the Formosan Medical Association
Volume 105, Issue 11 , Pages 918-925, 2006

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