Journal of the Formosan Medical Association
Volume 105, Issue 12 , Pages 1022-1026, 2006

Initial 10-year Experience of Sperm Cryopreservation Services for Cancer Patients

Department of Urology, College of Medicine, National Taiwan University, Taipei, Taiwan

Received 10 August 2005; received in revised form 20 October 2005; accepted 6 December 2005.

Article Outline

Offering sperm cryopreservation to preserve the fertility of male cancer patients is a relatively recent service in Asia. This study analyzed the types of cancer, timing of collection, sperm quality, and utilization for reproductive services by patients during a 10-year period at a medical center in Taiwan. A total of 75 oncology patients elected to freeze sperm for fertility preservation at our medical center during the initial 10 years of the availability of this service. The mean age of the patients was 25.7 years. Storage was discontinued in 13 (17%) patients and their survival duration was 13.1 ±11.1 months. The utilization rate of sperm cryo-preservation was 2.8% (75/2642). The types of cancer varied, with leukemia (35%), lymphoma (25%), and testicular cancer (13%) comprising the largest groups. A significantly lower sperm count was found in patients with chronic myelogenous leukemia, suggesting the need for earlier sperm collection after initiation of cancer treatment. Only three (4%) patients utilized their specimens for reproductive purposes. There was no clinical pregnancy during the study period, although one biochemical pregnancy was achieved. The low rates of sperm cryostorage for fertility preservation in cancer patients in this study suggest that there is a need for greater emphasis of this option for male oncology patients whose fertility is likely to be affected by chemotherapeutic treatment.

Key Words:  cancer , chemotherapy , cryopreservation , male infertility , sperm

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References 

  1. Miller RW , Young JL , Novakovic B . Childhood cancer . Cancer . 1995;75:395–405
  2. Castillo LA , Craft AW , Kernahan J , et al.   Gonadal function after 12-Gy testicular irradiation in childhood acute lym-phoblastic leukaemia . Med Pediatr Oncol . 1990;18:185–189
  3. Costabile RA . The effects of cancer and cancer therapy on male reproductive function . J Urol . 1993;149:1327–1330
  4. Schover LR , Brey K , Lichtin A , et al.   Oncologists' attitudes and practices regarding banking sperm before cancer treatment . J Clin Oncol . 2002;20:1890–1897
  5. Schover LR , Brey K , Lichtin A , et al.   Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors . J Clin Oncol . 2002;20:1880–1889
  6. Kelleher S , Wishart SM , Liu PY , et al.   Long-term outcomes of elective human sperm cryostorage . Hum Reprod . 2001;16:2632–2639
  7. Audrins P , Holden CA , McLachlan RI , et al.   Semen storage for special purposes at Monash IVF from 1977 to 1997 . Fertil Steril . 1999;72:179–181
  8. Lass A , Akagbosu F , Abusheikha N , et al.   A programme of semen cryopreservation for patients with malignant disease in a tertiary infertility centre: lessons from 8 years' experience . Hum Reprod . 1998;13:3256–3261
  9. Gandini L , Lombardo F , Salacone P , et al.   Testicular cancer and Hodgkin's disease: evaluation of semen quality . Hum Reprod . 2003;18:796–801
  10. Morrish DW , Venner PM , Siy O , et al.   Mechanisms of endocrine dysfunction in patients with testicular cancer . J Natl Cancer Inst . 1990;82:412–418
  11. Tal R , Botchan A , Hauser R , et al.   Follow-up of sperm concentration and motility in patients with lymphoma . Hum Reprod . 2000;15:1985–1988
  12. Khalifa E , Oehninger S , Acosta AA , et al.   Successful fertilization and pregnancy outcome in in vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases . Hum Reprod . 1992;7:105–108
  13. Meirow D , Schenker JG . Cancer and male infertility . Hum Reprod . 1995;10:2017–2022
  14. Meirow D , Schenker JG . Cancer and male infertility . Hum Reprod . 1995;10:2017–2022
  15. Rueffer U , Breuer K , Josting A , et al.   Male gonadal dysfunction in patients with Hodgkin's disease prior to treatment . Ann Oncol . 2001;12:1307–1311
  16. Botchan A , Hauser R , Gamzu R , et al.   Sperm quality in Hodgkin's disease versus non-Hodgkin's lymphoma . Hum Reprod . 1997;12:73–76
  17. Jemal A , Murray T , Ward E , et al.   Cancer statistics, 2005 . CA Cancer J Clin . 2005;55:10–30
  18. Chung K , Irani J , Knee G , et al.   Sperm cryopreservation for male patients with cancer: an epidemiological analysis at the University of Pennsylvania . Eur J Obstet Gynecol Reprod Biol . 2004;113(Suppl 1):S7–11

PII: S0929-6646(09)60288-6

doi:10.1016/S0929-6646(09)60288-6

Journal of the Formosan Medical Association
Volume 105, Issue 12 , Pages 1022-1026, 2006

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