Journal of the Formosan Medical Association
Volume 106, Issue 6 , Pages 499-503, 2007

Familial Sarcoidosis in Taiwan

  • Reury-Perng Perng

      Affiliations

    • Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    • School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Kun-Ta Chou

      Affiliations

    • Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Kun-Ta Chou, Chest Department, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan
    • ,
  • Hsi Chu

      Affiliations

    • Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
    • ,
  • Yu-Mei Chung

      Affiliations

    • School of Medicine, National Yang-Ming University, Taipei, Taiwan
    • Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan

Received 15 September 2006; received in revised form 9 October 2006; accepted 5 December 2006.

Article Outline

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology and is uncommon in Taiwan. No cases of familial sarcoidosis have been reported in Taiwan. In this article, we report a mother and son pair who had sarcoidosis. The 56-year-old mother sought medical help for chronic cough for 3 months in 1993. Enlarged mediastinal lymph nodes were demonstrated on chest computed tomography. Besides, two small erythematous papules on her face were observed. Mediastinoscopic biopsy and skin biopsy showed non-caseating granulomatous inflammation. Sarcoidosis was thus diagnosed. The human leukocyte antigen (HLA)-typing of the patient was HLA-A2, A11, B35, B39, CW4, CW7, DR8 and DQ6. Eleven years later, her son was also diagnosed with sarcoidosis proved by mediastinoscopic biopsy. His HLA-typing was HLA-A2, A24, B39, B48, CW7, CW8, DR8 and DQ6. This is the first report of familial sarcoidosis in Chinese people. More cases are needed for further investigation of genetic predisposition among Chinese people.

Key Words:  Chinese , familial sarcoidosis , human leukocyte antigen

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PII: S0929-6646(09)60301-6

doi:10.1016/S0929-6646(09)60301-6

Journal of the Formosan Medical Association
Volume 106, Issue 6 , Pages 499-503, 2007

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