Journal of the Formosan Medical Association
Volume 106, Issue 6 , Pages 509-512, 2007

Anthropometric and Intellectual Evaluation of Individuals with Prader-Willi Syndrome

  • San-Ging Shu

      Affiliations

    • Department of Pediatrics
    • Chung-Shan Medical University, Taichung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr San-Ging Shu, Department of Pediatrics, Taichung Veterans General Hospital, 160, Chung-Kang Road, Section 3, Taichung, Taiwan
    • ,
  • Shu Chien

      Affiliations

    • Genetic Center
    • ,
  • Yen-Ching Wu

      Affiliations

    • Department of Psychiatry, Taichung Veterans General Hospital
    • ,
  • Pei-Ling Tsai

      Affiliations

    • Department of Psychiatry, Taichung Veterans General Hospital
    • ,
  • Joung-Kun Yih

      Affiliations

    • Department of Psychiatry, Taichung Veterans General Hospital

Received 18 April 2006; received in revised form 8 August 2006; accepted 6 February 2007.

Article Outline

Prader-Willi syndrome (PWS) is a rare, multifaceted genetic disorder resulting from the absence of normally active paternally expressed genes from the 15q11-q13 chromosome region. Due to a lack of anthropometric and intellectual data in Taiwan, we attempted these evaluations. Twenty patients (14 males/6 females) aged 7–23 years with molecularly confirmed PWS were enrolled with parental consent. Their mean height standard deviation score (SDS) was −1.26 ± 1.89 (from −4.3 to +2.16); mean weight SDS was +1.77 ± 2.00 (from −0.44 to +5.89); mean body mass index SDS was +3.84 ± 10.54 (from −0.08 to +10.48); and mean body fat tissue SDS was 39.4 ± 10.54% (14.7-57.8%) by an InBody 3.0 analyzer. All were hypogonadal. Nine of them had once been given growth hormone therapy, and were taller and slimmer than the rest. Their in telligence tests showed full intelligence quotient = 52.0 ± 7.6; verbal intelligence quotient = 55.9 ± 8.77; performance intelligence quotient = 53.2 ± 9.0. Chronic health status revealed that diabetes was prevalent among the older population. Their IQ was in the range of those with moderate retardation.

Key Words:  anthropometric , body composition , intellectual , Prader-Willi syndrome

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PII: S0929-6646(09)60303-X

doi:10.1016/S0929-6646(09)60303-X

Journal of the Formosan Medical Association
Volume 106, Issue 6 , Pages 509-512, 2007

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