Journal of the Formosan Medical Association
Volume 106, Issue 2, Supplement , Pages S46-S50 , 2007

Slipped Capital Femoral Epiphysis as a Complication of Growth Hormone Therapy

  • Shuo-Yu Wang

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    • ,
  • Yi-Ching Tung

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Wen-Yu Tsai

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Wen-Yu Tsai, Department of Pediatrics, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan
    • ,
  • Yin-Hsiu Chien

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Jing-Sheng Lee

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    • ,
  • Wuh-Liang Hwu

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

Received 20 July 2005 ,Revised 4 November 2005 ,Accepted 7 March 2006.

References 

  1. Wilson TA , Rose SR , Cohen P , et al.   Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee . J Pediatr . 2003;143:415–421
  2. Blethen SL , Allen DB , Graves D , et al.   Safety of recombinant deoxyribonucleic acid-derived growth hormone: the National Cooperative Growth Study experience . J Clin Endocrinol Metab . 1996;81:1704–1710
  3. Maneatis T , Baptista J , Connelly K , et al.   Growth hormone safety update from the National Cooperative Growth Study . J Pediatr Endocrinol Metab . 2000;13(Suppl 2):1035–1044
  4. Blethen SL , Rundle AC . Slipped capital femoral epiphysis in children treated with growth hormone. A summary of the National Cooperative Growth Study experience . Horm Res . 1996;46:113–116
  5. Rappaport EB , Fife D . Slipped capital femoral epiphysis in growth hormone-deficient patients . Am J Dis Child . 1985;139:396–399
  6. Kelsey JL . The incidence and distribution of slipped capital femoral epiphysis in Connecticut . J Chronic Dis . 1971;23:567–578
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  8. Docquier PL , Mousny M , Jouret M , et al.   Orthopaedic concerns in children with growth hormone therapy . Acta Orthop Belg . 2004;70:299–305
  9. Causey AL , Smith ER , Donaldson JJ , et al.   Missed slipped capital femoral epiphysis: illustrative cases and a review . J Emerg Med . 1995;13:175–189
  10. Moreira JF , Neves MC , Lopes G , et al.   Slipped capital femoral epiphysis. A report of 4 cases occurring in one family . Int Orthop . 1998;22:193–196
  11. Chapman JA , Deakin DP , Green JH . Slipped upper femoral epiphysis after radiotherapy . J Bone Joint Surg Br . 1980;62:337–339
  12. Wells D , King JD , Roe TF , et al.   Review of slipped capital femoral epiphysis associated with endocrine disease . J Pediatr Orthop . 1993;13:610–614
  13. Harris WR . The endocrine basis for slipping of the upper femoral epiphysis. An experimental study . J Bone Joint Surg Br . 1950;32:5–11
  14. Yang WE , Shih CH , Wang KC , et al.   Slipped capital femoral epiphyses in a patient with primary hyperparathyroidism . J Formos Med Assoc . 1997;96:549–552
  15. Reeves GD , Gibbs M , Paulshock BZ , et al.   Gigantism with slipped capital femoral epiphysis . Am J Dis Child . 1978;132:529–530
  16. West LA , Ballock RT . High incidence of hip dysplasia but not slipped capital femoral epiphysis in patients with Prader-Willi syndrome . J Pediatr Orthop . 2004;24:565–567
  17. Carrel AL , Myers SE , Whitman BY , et al.   Benefits of long-term GH therapy in Prader-Willi syndrome: a 4-year study . J Clin Endocrinol Metab . 2002;87:1581–1585
  18. Reynolds RA . Diagnosis and treatment of slipped capital femoral epiphysis . Curr Opin Pediatr . 1999;11:80–83
  19. Perron AD , Miller MD , Brady WJ . Orthopedic pitfalls in the ED: slipped capital femoral epiphysis . Am J Emerg Med . 2002;20:484–487
  20. Matava MJ , Patton CM , Luhmann S , et al.   Knee pain as the initial symptom of slipped capital femoral epiphysis: an analysis of initial presentation and treatment . J Pediatr Orthop . 1999;19:455–460
  21. Loder RT , Wittenberg B , DeSilva G . Slipped capital femoral epiphysis associated with endocrine disorders . J Pediatr Orthop . 1995;15:349–356

PII: S0929-6646(09)60352-1

doi: 10.1016/S0929-6646(09)60352-1

Journal of the Formosan Medical Association
Volume 106, Issue 2, Supplement , Pages S46-S50 , 2007

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