Journal of the Formosan Medical Association
Volume 106, Issue 3, Supplement , Pages S1-S4, 2007

Hepatic Mesenchymal Hamartoma Combined with Infantile Hepatic Hemangioendothelioma in an Infant

  • Kuang-Hung Hsiao

      Affiliations

    • Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan
    • ,
  • Lung-Huang Lin

      Affiliations

    • Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Lung-Huang Lin, Department of Pediatrics, Cathay General Hospital, 280, Section 4, Jen-Ai Road, Taipei 106, Taiwan
    • ,
  • Der-Fang Chen

      Affiliations

    • Department of Pediatric Surgery, Cathay General Hospital, Taipei, Taiwan
    • ,
  • Shih-Hung Huang

      Affiliations

    • Department of Pathology, Cathay General Hospital, Taipei, Taiwan

Received 4 November 2005; received in revised form 21 December 2005; accepted 2 May 2006.

Article Outline

Hepatic mesenchymal hamartoma is a rare benign tumor in children, and infantile hepatic hemangioendothelioma is also a rare liver neoplasm. We report a female newborn with an abdominal mass noted by the regular maternal ultrasound at 32 weeks of gestation. After birth, a liver mass was detected by computed tomography and magnetic resonance cholangiopancreatography. Frequent postprandial vomiting and progressive abdominal distension occurred 4 months later. Three tumor masses were detected this time, and the serum alpha-fetoprotein (AFP) was 6700 ng/mL. Segmental resection was performed initially and complete resection of these tumors and left lobectomy were performed 21 days later. Pathologic examination of these liver masses revealed mesenchymal hamartoma combined with infantile hepatic hemangioendothelioma. After half a year of regular follow-up, the AFP level decreased gradually to 79.5 ng/mL, without evidence of tumor recurrence. [J Formos Med Assoc 2007;106(3 Suppl):S1-S4]

Key Words:  hepatic hemangioendothelioma , hepatic mesenchymal hamartoma , infant

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Weinberg AG , Finegold MJ . Primary hepatic tumors of childhood . Hum Pathol . 1983;14:512–537
  2. Mulrooney DA , Carpenter B , Georgieff M , et al.   Hepatic mesenchymal hamartoma in a neonate: a case report and review of the literature . J Pediatr Hematol Oncol . 2001;23:316–317
  3. Stocker JT . Hepatic tumors in children . Clin Liver Dis . 2001;5:259–281
  4. Stocker JT , Ishak KG . Mesenchymal hamartoma of the liver: report of 30 cases and review of the literature . Pediatr Pathol . 1983;1:245–267
  5. Powers C , Ros PR , Stoupis C , et al.   Primary liver neoplasms: MR imaging with pathological correlation . Radiographics . 1994;14:459–482
  6. Rakheja D , Margraf LR , Tomlinson GE , et al.   Hepatic mesenchymal hamartoma with translocation involving chromosome band 19q13.4: a recurrent abnormality . Cancer Genet Cytogenet . 2004;153:60–63
  7. Ito H , Kishikawa T , Toda T , et al.   Hepatic mensenchymal hamartoma of an infant . J Pediatr Surg . 1984;19:315–317
  8. Caty MG , Shamberger RC . Abdominal tumors in infancy and childhood . Pediatr Clin North Am . 1993;40:1253–1271
  9. Spleleman F , De Telder V , De Potter KR , et al.   Cytogenetic analysis of a mesenchymal hamartoma of the liver . Cancer Genet Cytogenet . 1989;40:29–32
  10. Roebuck DJ . Hemangioendothelioma of the liver in infants . J Pediatr Surg . 1995;30:1632
  11. Samuel M , Spitz L . Infantile hepatic hemangioendothelioma: the role of surgery . J Pediatr Surg . 1995;30:1425–1429
  12. Donnelly LF , Bisset GS . Pediatric hepatic imaging . Radiol Clin North Am . 1998;36:413–427
  13. Chen CC , Kong MS , Yang CP . Hepatic hemangioendothelioma in children: analysis of thirteen cases . Acta Paediatr Taiwan . 2003;44:8–13
  14. Han SJ , Tsai CC , Tsai HM , et al.   Infantile hemangioendothelioma with a highly elevated serum alpha-fetoprotein level . Hepatogastroenterology . 1998;45:459–461
  15. Seo IS , Min KW , Mirkin LD . Hepatic hemangioendothelioma of infancy associated with elevated alpha fetoprotein and catecholamine by-products . Pediatr Pathol . 1988;8:625–631
  16. Selby DM , Stocker JT , Waclawiw MA , et al.   Infantile hemangioendothelioma of the liver . Hepatology . 1994;20:39–45
  17. Doller JA , Bueno J , Gutierrez J , et al.   Hepatic hemangioendothelioma: clinical experience and management strategy . J Pediatr Surg . 1999;34:98–106
  18. Bejarano PA , Serrano MF , Casillas J , et al.   Concurrent infantile hemangioendothelioma and mesenchymal hamartoma in a developmentally arrested liver of an infant requiring hepatic transplantation . Pediatr Dev Pathol . 2003;6:552–557

PII: S0929-6646(09)60357-0

doi:10.1016/S0929-6646(09)60357-0

Journal of the Formosan Medical Association
Volume 106, Issue 3, Supplement , Pages S1-S4, 2007

Article Tools