Journal of the Formosan Medical Association
Volume 106, Issue 3, Supplement , Pages S15-S19, 2007

Coexistence of Ovarian Cancer and Renal Cell Carcinoma

  • Kuo-How Huang

      Affiliations

    • Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Shih-Dong Chung

      Affiliations

    • Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Shin-Yi Huang

      Affiliations

    • Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    • Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Shih-Chieh Chueh

      Affiliations

    • Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Shih-Chieh Chueh, Department of Urology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan
    • ,
  • Chi-An Chen

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Jun Chen

      Affiliations

    • Department of Urology, National Taiwan University Hospital, Taipei, Taiwan

Received 22 June 2005; received in revised form 17 October 2005; accepted 4 April 2006.

Article Outline

Coexistence of ovarian cancer and renal cell carcinoma (RCC) is extremely rare. Only one case was diagnosed in a total of 584 patients with RCC from 1982 to 2002 at our hospital. A 58-year-old woman presented with an enlarged girdle length for 3 months. Computed tomography scan showed a right cystic adnexal mass measuring 10 × 10 cm, and another tumor measuring 3 × 2 cm at the right kidney. She underwent debulking surgery and radical nephrectomy. Pathologic examination revealed right ovarian clear-cell carcinoma with peritoneal, omental, and fallopian tube metastasis, and conventional clear-cell renal carcinoma. RCC was strongly positive in epithelial membrane antigen (EMA) staining and negative in estrogen receptors (ER), progesterone receptors (PR), 34bE12 (high molecular weight cytokeratin), and vimentin staining. Ovarian clear-cell carcinoma showed weakly positive results in EMA staining and negative results in ER, PR, 34bE12, and vimentin staining. Although chemotherapy was given, the patient died of disseminated ovarian cancer metastasis 20 months after operation. In conclusion, coexistence of RCC and ovarian cancer is rare and the pathogenesis remains to be clarified. [J Formos Med Assoc 2007;106(3 Suppl):S15-S19]

Key Words:  ovarian cancer , renal cell carcinoma , synchronous tumors

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PII: S0929-6646(09)60360-0

doi:10.1016/S0929-6646(09)60360-0

Journal of the Formosan Medical Association
Volume 106, Issue 3, Supplement , Pages S15-S19, 2007

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