Journal of the Formosan Medical Association
Volume 108, Issue 10 , Pages 778-787 , October 2009

Key Process Indicators of Mortality in the Implementation of Protocol-driven Therapy for Severe Sepsis

  • Jiun-Long Wang

      Affiliations

    • Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    • Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan
  • ,
  • Chun-Shih Chin

      Affiliations

    • Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
  • ,
  • Ming-Chen Chang

      Affiliations

    • Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
  • ,
  • Chi-Yuan Yi

      Affiliations

    • Department of Nursing, Taichung Veterans General Hospital, Taichung, Taiwan
  • ,
  • Sou-Jen Shih

      Affiliations

    • Department of Nursing, Taichung Veterans General Hospital, Taichung, Taiwan
  • ,
  • Jeng-Yuan Hsu

      Affiliations

    • Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    • Institute of Medicine, Chung-Shan Medical University, Taichung, Taiwan
  • ,
  • Chieh-Liang Wu

      Affiliations

    • Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    • Department of Life Science, National Chung-Hsing University, Taichung, Taiwan
    • School of Medicine, China Medical University, Taichung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Chieh-Liang Wu, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Section 3, Chung-Kang Road, Taichung 407, Taiwan

Received 14 November 2008 ,Revised 5 January 2009 ,Accepted 4 February 2009.

References 

  1. Rivers E , Nguyen B , Havstad S , et al.   Early goal-directed therapy in the treatment of severe sepsis and septic shock . N Engl J Med . 2001;345:1368–1377
  2. Dellinger RP , Carlet JM , Masur H , et al.   Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock . Crit Care Med . 2004;32:858–873
  3. Talmor D , Greenberg D , Howell MD , et al.   The costs and cost-effectiveness of an integrated sepsis treatment protocol . Crit Care Med . 2008;36:1168–1174
  4. Talmor D , Shapiro N , Greenberg D , et al.   When is critical care medicine cost-effective? A systematic review of the cost-effectiveness literature . Crit Care Med . 2006;34:2738–2747
  5. Otero RM , Nguyen HB , Huang DT , et al.   Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings . Chest . 2006;130:1579–1595
  6. Trzeciak S , Dellinger RP , Abate NL , et al.   Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department . Chest . 2006;129:225–232
  7. Angus DC , Linde-Zwirble WT , Lidicker J , et al.   Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care . Crit Care Med . 2001;29:1303–1310
  8. Gao F , Melody T , Daniels DF , et al.   The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study . Crit Care . 2005;9:R764–R770
  9. Alberti C , Brun-Buisson C , Burchardi H , et al.   Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study . Intensive Care Med . 2002;28:108–121
  10. Nguyen HB , Corbett SW , Steele R , et al.   Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality . Crit Care Med . 2007;35:1105–1112
  11. Ferrer R , Artigas A , Levy MM , et al.   Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain . JAMA . 2008;299:2294–2303
  12. Kortgen A , Niederprum P , Bauer M . Implementation of an evidence-based “standard operating procedure” and outcome in septic shock . Crit Care Med . 2006;34:943–949
  13. Shapiro NI , Howell MD , Talmor D , et al.   Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol . Crit Care Med . 2006;34:1025–1032
  14. Bone RC , Balk RA , Cerra FB , et al.   Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/ Society of Critical Care Medicine . Chest . 1992;101:1644–1655
  15. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network . N Engl J Med . 2000;342:1301–1308
  16. Levy MM , Macias WL , Vincent JL , et al.   Early changes in organ function predict eventual survival in severe sepsis . Crit Care Med . 2005;33:2194–2201
  17. Lundberg JS , Perl TM , Wiblin T , et al.   Septic shock: an analysis of outcomes for patients with onset on hospital wards versus intensive care units . Crit Care Med . 1998;26:1020–1024
  18. Rivers EP . Early goal-directed therapy in severe sepsis and septic shock: converting science to reality . Chest . 2006;129:217–218
  19. Karlsson S , Varpula M , Ruokonen E , et al.   Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study . Intensive Care Med . 2007;33:435–443
  20. Brower RG , Rubenfeld GD . Lung-protective ventilation strategies in acute lung injury . Crit Care Med . 2003;31:S312–S316
  21. Dellinger RP , Levy MM , Carlet JM , et al.   Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 . Crit Care Med . 2008;36:296–327
  22. Gillis RC , Weireter LJ , Britt RC , et al.   Lung protective ventilation strategies: have we applied them in trauma patients at risk for acute lung injury and acute respiratory distress syndrome? . Am Surg . 2007;73:347–350
  23. Haas CF . Lung protective mechanical ventilation in acute respiratory distress syndrome . Respir Care Clin N Am . 2003;9:363–396
  24. Marini JJ , Gattinoni L . Ventilatory management of acute respiratory distress syndrome: a consensus of two . Crit Care Med . 2004;32:250–255
  25. Petrucci N , Iacovelli W . Lung protective ventilation strategy for the acute respiratory distress syndrome . Cochrane Database Syst Rev . 2007; CD003844.
  26. Steinberg KP , Kacmarek RM . Respiratory controversies in the critical care setting. Should tidal volume be 6 mL/kg predicted body weight in virtually all patients with acute respiratory failure? . Respir Care . 2007;52:556–567

PII: S0929-6646(09)60405-8

doi: 10.1016/S0929-6646(09)60405-8

Journal of the Formosan Medical Association
Volume 108, Issue 10 , Pages 778-787 , October 2009