Journal of the Formosan Medical Association
Volume 109, Issue 2 , Pages 91-93 , February 2010

Pyrrole-Imidazole Polyamide: A Novel Gene Silencer and its Potential Use in Drug-eluting Stents

  • Zi-Wen Zhao
    • ,
  • En-Hui Yao
    • ,
  • Liang-Long Chen

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Liang-Long Chen, Department of Cardiology, Union Hospital, Fujian Medical University, 29 Xin-Quan Road, Fuzhou 350001, China

References 

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  6. Matsuda H , Fukuda N , Ueno T , et al.   Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-β1 promoter for treatment of progressive renal diseases . J Am Soc Nephrol . 2006;17:422–432
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  9. Yao EH , Fukuda N , Ueno T , et al.   A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery . Cardiovasc Res . 2009;81:797–804
  10. Yao EH , Fukuda N , Ueno T , et al.   Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury . Hypertension . 2008;52:86–92
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  12. Tanguay JF . Vascular healing after stenting: the role of 17-beta-estradiol in improving re-endothelialization and reducing restenosis . Can J Cardiol . 2005;21:1025–1030
  13. Ashley EA , Ferrara R , King JY , et al.   Network analysis of human in-stent restenosis . Circulation . 2006;114:2644–2654
  14. Kopp CW , de Martin R . Gene therapy approaches for the prevention of restenosis . Curr Vasc Pharmacol . 2004;2:183–189
  15. Mitra AK , Agrawal DK . Gene therapy of fibroproliferative vasculopathies: current ideas in molecular mechanisms and biomedical technology . Pharmacogenomics . 2006;7:1185–1198

PII: S0929-6646(10)60028-9

doi: 10.1016/S0929-6646(10)60028-9

Journal of the Formosan Medical Association
Volume 109, Issue 2 , Pages 91-93 , February 2010

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