Journal of the Formosan Medical Association
Volume 109, Issue 3 , Pages 237-240, March 2010

Secondary Hypertension due to a Renin-secreting Juxtaglomerular Cell Tumor

  • Shih-Yi Lin

      Affiliations

    • Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan
    • ,
  • Wayne-Young Liu

      Affiliations

    • Department of Urology, Jen Ai Hospital, Taichung, Taiwan
    • ,
  • Wen-Chi Chen

      Affiliations

    • Department of Urology, China Medical University Hospital, China Medical University, Taichung, Taiwan
    • ,
  • Rong-Hsing Chen

      Affiliations

    • Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Rong-Hsing Chen, Department of Internal Medicine, China Medical University Hospital, China Medical University, 2 Yuh-Der Road, Taichung 404, Taiwan

Received 14 January 2008; received in revised form 15 April 2008; accepted 10 June 2008.

Article Outline

A juxtaglomerular cell tumor (JCT) is a rare, renin-secreting tumor of the kidney and can cause hypertension. JCT is pathologically benign, and resection of the tumor is curative for hypertension. We report the case of a 17-year-old girl who had hypertension and hypokalemia for 1 year. Laboratory studies showed increased basal plasma renin activity, but normal serum aldosterone level. Abdominal computed tomography disclosed a 2 cm solid mass in the left kidney. However, renal vein sampling and captopril test results were equivocal. Partial nephrectomy was performed and histologic examination demonstrated typical features of JCT. Hypertension and hypokalemia completely resolved postoperatively. JCT should be considered when investigating hypertensive individuals with high plasma renin activity.

Key Words:  hypertension , juxtaglomerular cell , plasma renin activity , renin-secreting tumor

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PII: S0929-6646(10)60047-2

doi:10.1016/S0929-6646(10)60047-2

Journal of the Formosan Medical Association
Volume 109, Issue 3 , Pages 237-240, March 2010

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