Journal of the Formosan Medical Association
Volume 109, Issue 5 , Pages 326-337 , May 2010

Decreased GRP78 Protein Expression is a Potential Prognostic Marker of Oral Squamous Cell Carcinoma in Taiwan

  • Tze-Ta Huang

      Affiliations

    • Dental Department, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • School of Medicine, Tzu Chi University, Hualian, Taiwan
  • ,
  • Jeff Yi-Fu Chen

      Affiliations

    • Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
  • ,
  • Chih-En Tseng

      Affiliations

    • Department of Pathology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • School of Medicine, Tzu Chi University, Hualian, Taiwan
  • ,
  • Yu-Chieh Su

      Affiliations

    • Division of Hematology-Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • School of Medicine, Tzu Chi University, Hualian, Taiwan
  • ,
  • Hsu-Chueh Ho

      Affiliations

    • Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • School of Medicine, Tzu Chi University, Hualian, Taiwan
  • ,
  • Moon-Sing Lee

      Affiliations

    • Division of Radiotherapy and Radiooncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan
    • School of Medicine, Tzu Chi University, Hualian, Taiwan
  • ,
  • Chiou-Tuz Chang

      Affiliations

    • Dental Department, Taichung Veterans General Hospital, Taichung, Taiwan
  • ,
  • Yong-Kie Wong

      Affiliations

    • Dental Department, Taichung Veterans General Hospital, Taichung, Taiwan
  • ,
  • Hau-Ren Chen

      Affiliations

    • Department of Life Science, Institute of Molecular Biology and Institute of Biomedical Science, National Chung Cheng University, Chiayi, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Hau-Ren Chen, Department of Life Science, Institute of Molecular Biology, and Institute of Biomedical Science, National Chung Cheng University, 168 University Road, Min-Hsiung, Chia-Yi, Taiwan

Received 10 June 2008 ,Revised 16 November 2008 ,Accepted 20 August 2009.

References 

  1. Lin YS , Jen YM , Wang BB , et al.   Epidemiology of oral cavity cancer in Taiwan with emphasis on the role of betel nut chewing . ORL J Otorhinolaryngol Relat Spec . 2005;67:230–236
  2. Department of Health Annual Statistics Information Service  . Mortality Rates for 2006 . Available at: http://www.doh.gov.tw/EN2006/DM/DM2.aspx?now_fod_list_no=9377&class_no=390&level_no=2 [Date accessed: April 29, 2010]
  3. Bureau of Health Promotion  , Department of Health, ROC  . Cancer Registry Annual Report . Available at: http://tcr.cph.ntu.edu.tw/main.php?Page=N2 2006; [Date accessed: April 29, 2010]
  4. Liaw GA , Yen CY , Chiang WF , et al.   Outcome of treatment with total main tumor resection and supraomohyoid neck dissection in oral squamous cell carcinoma . J Formos Med Assoc . 2006;105:971–977
  5. Chen PH , Shieh TY , Ho PS , et al.   Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan . BMC Cancer . 2007;7:101
  6. He QY , Chen J , Kung HF , et al.   Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics . Proteomics . 2004;4:271–278
  7. Chen J , He QY , Yuen AP , et al.   Proteomics of buccal squamous cell carcinoma: The involvement of multiple pathways in tumorigenesis . Proteomics . 2004;4:2465–2475
  8. Wong DY , Chang KW , Chen CF , et al.   Characterization of two new cell lines derived from oral cavity human squamous cell carcinomas - OC1 and OC2 . J Oral Maxillofac Surg . 1990;48:385–390
  9. Petty RD , Sutherland LA , Hunter EM , et al.   Comparison of MTT and ATP-based assays for the measurement of viable cell number . J Biolumin Chemilumin . 1995;10:29–34
  10. Veenstra TD , Yates JR . Proteomics for Biological Discovery . Hoboken, NJ: John Wiley & Sons; 2006;
  11. Matrix Science . Available at http://matrixscience.com [Date accessed: April 29, 2010]
  12. Hendershot LM . The ER function Bip is a master regulator of ER function . Mt Sinai J Med . 2004;71:289–297
  13. Rao RV , Peel A , Logvinova A , et al.   Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78 . FEBS Lett . 2002;514:122–128
  14. Uramoto H , Sugio K , Oyama T , et al.   Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance . Lung Cancer . 2005;49:55–62
  15. Li J , Lee AS . Stress induction of Grp78/Bip and its role in cancer . Curr Mol Med . 2006;6:45–54
  16. Wang XP , Liao J , Liu GZ , et al.   Co-expression of heat shock protein 70 and glucose-regulated protein 94 in human gastric carcinoma cell line BGC-823 . World J Gastroenterol . 2005;11:3601–3604
  17. Hfaiedh N , Allagui MS , El Feki A , et al.   Effects of nickel poisoning on expression pattern of the 72/73 and 94 kDa stress proteins in rat organs and in the COS-7, HepG2, and A549 cell lines . J Biochem Mol Toxicol . 2005;19:12–18
  18. Ramakrishnan M , Schönthal AH , Lee AS . Endoplasmic reticulum stress-inducible protein GRP94 is associated with an Mg2+-dependent serine kinase activity modulated by Ca2+ and GRP78/BiP . J Cell Physiol . 1997;170:115–129
  19. Vastag B . HSP-90 inhibitors promise to complement cancer therapies . Nat Biotechnol . 2006;24:1037
  20. Lässle M , Blatch GL , Kundra V , et al.   Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases . J Biol Chem . 1997;272:1876–1884
  21. Qi YJ , He QY , Ma YF , et al.   Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma . J Cell Biochem . 2008;104:1625–1635
  22. Onoue T , Uchida D , Begum NM , et al.   Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells . Int J Oncol . 2006;29:1133–1138
  23. Hernández-Vargas H , Rodríguez-Pinilla SM , Julián-Tendero M , et al.   Gene expression profiling of breast cancer cells in response to gemcitabine: NF-κB pathway activation as a potential mechanism of resistance . Breast Cancer Res Treat . 2007;102:157–172
  24. Raynal P , Pollard HB . Annexins. The problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipids-binding proteins . Biochem Biophys Acta . 1994;1197:63–69
  25. Singh P . Role of annexin-II in GI cancers: interaction with gastrins/progastrins . Cancer Lett . 2007;252:19–35
  26. Garcia Pedrero JM , Fernandez MP , Morgan RO , et al.   Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status . Am J Pathol . 2004;164:73–79
  27. Lin CY , Jeng YM , Chou HY , et al.   Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma . J Surg Oncol . 2008;97:544–550
  28. Merrick WC . Mechanism and regulation of eukaryotic protein synthesis . Microbiol Mol Biol Rev . 1992;56:291–315
  29. Nystrom ML , McCulloch D , Weinreb PH , et al.   Cyclooxygenase-2 inhibition suppresses αvβ6 integrin-dependent oral squamous carcinoma invasion . Cancer Res . 2006;66:10833–10842

PII: S0929-6646(10)60060-5

doi: 10.1016/S0929-6646(10)60060-5

Journal of the Formosan Medical Association
Volume 109, Issue 5 , Pages 326-337 , May 2010