Journal of the Formosan Medical Association
Volume 109, Issue 5 , Pages 354-361 , May 2010

Clinical and Genetic Analysis of Peutz-Jeghers Syndrome Patients in Taiwan

  • Meng-Tzu Weng

      Affiliations

    • Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan
    • ,
  • Yen-Hsuan Ni

      Affiliations

    • Department of Pediatrics, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    • ,
  • Yi-Nien Su

      Affiliations

    • Department of Medical Genetics, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    • ,
  • Jau-Min Wong

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    • ,
  • Shu-Chen Wei

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Shu-Chen Wei, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan

Received 20 April 2009 ,Revised 11 June 2009 ,Accepted 22 July 2009.

References 

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  3. Giardiello FM , Brensinger JD , Tersmette AC , et al.   Very high risk of cancer in familial Peutz-Jeghers syndrome . Gastroenterology . 2000;119:1447–1453
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  5. Hemminki A , Markie D , Tomlinson I , et al.   A serine/threo-nine kinase gene defective in Peutz-Jeghers syndrome . Nature . 1998;391:184–187
  6. Aaltonen LJH , Gruber S . Peutz-Jehgers syndrome . In:  Hamilton S ,  Aaltonen L editor. Tumours of the Digestive System . Lyon: IACR; 2000;p. 74–76
  7. McGarrity TJ , Amos C . Peutz-Jeghers syndrome: clinicopathology and molecular alterations . Cell Mol Life Sci . 2006;63:2135–2144
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  10. Utsunomiya J , Gocho H , Miyanaga T , et al.   Peutz-Jeghers syndrome: its natural course and management . Johns Hopkins Med J . 1975;136:71–82
  11. Giardiello FM , Welsh SB , Hamilton SR , et al.   Increased risk of cancer in the Peutz-Jeghers syndrome . N Engl J Med . 1987;316:1511–1514
  12. Hizawa K , Iida M , Matsumoto T , et al.   Cancer in Peutz-Jeghers syndrome . Cancer . 1993;72:2777–2781
  13. Yoon KA , Ku JL , Choi HS , et al.   Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients . Br J Cancer . 2000;82:1403–1406
  14. Ylikorkala A , Avizienyte E , Tomlinson IP , et al.   Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer . Hum Mol Genet . 1999;8:45–51
  15. Amos CI , Keitheri-Cheteri MB , Sabripour M , et al.   Genotype-phenotype correlations in Peutz-Jeghers syndrome . J Med Genet . 2004;41:327–333

PII: S0929-6646(10)60063-0

doi: 10.1016/S0929-6646(10)60063-0

Journal of the Formosan Medical Association
Volume 109, Issue 5 , Pages 354-361 , May 2010

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