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Volume 109, Issue 7, Pages 484-492 (July 2010)


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Intra-abdominal Complications of Sarcoidosis

Kristin Loening MacArthura, Faripour Forouharb, George Yung-Hsing WuaCorresponding Author Informationemail address

Sarcoidosis is an inflammatory disease characterized by non-caseating granulomas in the absence of other autoimmune processes, infectious diseases, or foreign agents. The etiology of sarcoidosis is not completely understood. Several organ systems can be affected, of which the most frequently involved include the lungs and lymph nodes. Intra-abdominal sarcoidosis is less common, but can be found in the absence of pulmonary or lymphatic disease. Intra-abdominal sarcoidosis is most often asymptomatic. However, long-standing unrecognized disease can result in life-threatening complications. The identification, monitoring and prevention of these complications will be discussed, with emphasis on both clinical and histological presentations of intra-abdominal sarcoidosis.

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1. 1 Baughman RP , Lower EE . Sarcoidosis . In:  Fauci A ,  Braunwald E ,  Kasper DL ,  Hauser SL ,  Longo DL ,  Jameson JL ,  Loscalzo J editor. Harrison's principles of internal medicine . 17th edition. New York: McGraw Hill; 2008; .

2. 2 Perng RP , Chou KT , Chu H , et al.   Familial sarcoidosis in Taiwan . J Formos Med Assoc . 2007;106:499–503 . Abstract | Full-Text PDF (345 KB) | CrossRef

3. 3 Rybicki BA , Major M , Popovich J , et al.   Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization . Am J Epidemiol . 1997;145:234–241 . MEDLINE

4. 4 Iwai K , Tachibana T , Takemura T , et al.   Pathological studies on sarcoidosis autopsy. I. Epidemiological features of 320 cases in Japan . Acta Pathol Jpn . 1993;43:372–376 . MEDLINE

5. 5 Costabel U , Hunninghake GW . ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders . Eur Respir J . 1999;14:735–737 . MEDLINE | CrossRef

6. 6 Perng RP , Chen JH , Tsai TT , et al.   Sarcoidosis among Chinese in Taiwan . J Formos Med Assoc . 1997;96:697–699 . MEDLINE

7. 7 Anantham D , Ong SJ , Chuah KL , et al.   Sarcoidosis in Singapore: epidemiology, clinical presentation and ethnic differences . Respirology . 2007;12:355–360 . MEDLINE | CrossRef

8. 8 Iwai K , Tachibana T , Hosoda Y , et al.   Sarcoidosis autopsies in Japan. Frequency and trend in the last 28 years . Sarcoidosis . 1988;5:60–65 . MEDLINE

9. 9 Ebert EC , Kierson M , Hagspiel KD . Gastrointestinal and hepatic manifestations of sarcoidosis . Am J Gastroenterol . 2008;103:3184–3192 quiz 3193. . CrossRef

10. 10 Israel HL , Sones M . Sarcoidosis; clinical observation on one hundred sixty cases . AMA Arch Intern Med . 1958; .

11. 11 Akinyemi E , Rohewal U , Tangorra M , et al.   Gastric sarcoidosis . J Natl Med Assoc . 2006;98:948–949 . MEDLINE

12. 12 Longcope WT , Freiman DG . A study of sarcoidosis; based on a combined investigation of 160 cases including 30 autopsies from The Johns Hopkins Hospital and Massachusetts General Hospital . Medicine (Baltimore) . 1952;31:1–132 . MEDLINE | CrossRef

13. 13 Vahid B , Spodik M , Braun KN , et al.   Sarcoidosis of gastrointestinal tract: a rare disease . Dig Dis Sci . 2007;52:3316–3320 . CrossRef

14. 14 Chesnutt MS , Gifford AH , Prendergast TJ . Pulmonary disorders . In:  McPhee SJ ,  Papadakis MA ,  Tierney LM editor. Current medical diagnosis & treatment 2010 . 49th edition. New York: McGraw-Hill; 2010; .

15. 15 Lazarus A . Sarcoidosis: epidemiology, etiology, pathogen-esis, and genetics . Dis Mon . 2009;55:649–660 . Full Text | Full-Text PDF (229 KB) | CrossRef

16. 16 Chen ESD , Moller DR . Sarcoidosis . In:  Imboden JB ,  Hellman DB ,  Stone JH editor. Current Rheumatology Diagnosis and Treatment . 2nd edition. New York: McGraw Hill; 2004; .

17. 17 Harder H , Büchler MW , Fröhlich B , et al.   Extrapulmonary sarcoidosis of liver and pancreas: a case report and review of literature . World J Gastroenterol . 2007;13:2504–2509 . MEDLINE

18. 18 Israel HL , Margolis ML , Rose LJ . Hepatic granulomatosis and sarcoidosis. Further observations . Dig Dis Sci . 1984;29:353–356 . MEDLINE | CrossRef

19. 19 Blich M , Edoute Y . Clinical manifestations of sarcoid liver disease . J Gastroenterol Hepatol . 2004;19:732–737 . MEDLINE | CrossRef

20. 20 Valla D , Pessegueiro-Miranda H , Degott C , et al.   Hepatic sarcoidosis with portal hypertension. A report of seven cases with a review of the literature . Q J Med . 1987;63:531–544 . MEDLINE

21. 21 Deniz K , Ward SC , Rosen A , et al.   Budd-Chiari syndrome in sarcoidosis involving liver . Liver Int . 2008;28:580–581 .

22. 22 Malhotra A , Naniwadekar A , Sood G . Hepatobiliary and pancreatic: cirrhosis secondary to hepatic sarcoidosis . J Gastroenterol Hepatol . 2008;23:1942 . CrossRef

23. 23 Gupta S , Faughnan ME , Prud'homme GJ , et al.   Sarcoidosis complicated by cirrhosis and hepatopulmonary syndrome . Can Respir J . 2008;15:124–126 .

24. 24 Chalasani P , Vohra M , Sheagren JN . An association of sar-coidosis with hepatocellular carcinoma . Ann Oncol . 2005;16:1714–1715 . MEDLINE | CrossRef

25. 25 Wong VS , Adab N , Youngs GR , et al.   Hepatic sarcoidosis complicated by hepatocellular carcinoma . Eur J Gastroenterol Hepatol . 1999;11:353–355 . CrossRef

26. 26 Vatti R , Sharma OP . Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases . Sarcoidosis Vasc Diffuse Lung Dis . 1997;14:73–76 . MEDLINE

27. 27 Silverstein E , Friedland J , Kitt M , et al.   Increased serum angiotensin converting enzyme activity in sarcoidosis . Isr J Med Sci . 1977;13:995–1000 .

28. 28 Lieberman J . Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis . Am J Med . 1975;59:365–372 . Abstract | Full-Text PDF (910 KB) | CrossRef

29. 29 Koyama T , Ueda H , Togashi K , Umeoka S , Kataoka M , Nagai S . Radiologic manifestations of sarcoidosis in various organs . Radiographics . 2004;24:87–104 . CrossRef

30. 30 Rose AS , Tielker MA , Knox KS . Hepatic, ocular, and cutaneous sarcoidosis . Clin Chest Med . 2008;29:509–524 ix. . Abstract | Full Text | Full-Text PDF (1630 KB) | CrossRef

31. 31 Kennedy PT , Zakaria N , Modawi SB , et al.   Natural history of hepatic sarcoidosis and its response to treatment . Eur J Gastroenterol Hepatol . 2006;18:721–726 . CrossRef

32. 32 Doty JD , Mazur JE , Judson MA . Treatment of sarcoidosis with infliximab . Chest . 2005;127:1064–1071 . MEDLINE | CrossRef

33. 33 Baughman RP . Methotrexate for sarcoidosis . Sarcoidosis Vasc Diffuse Lung Dis . 1998;15:147–149 . MEDLINE

34. 34 Bécheur H , Dall'osto H , Chatellier G , et al.   Effect of ursodeoxycholic acid on chronic intrahepatic cholestasis due to sarcoidosis . Dig Dis Sci . 1997;42:789–791 . MEDLINE | CrossRef

35. 35 Wasfi YS , Margolis ML . A 45-year-old man with severe dys-phagia and pulmonary infiltrates . Chest . 2007;131:1256–1259 . MEDLINE | CrossRef

36. 36 Ohshimo S , Theegarten D , Tötsch M , Moege  , et al.   Esophageal sarcoidosis presenting as pseudodiverticulum . Sarcoidosis Vasc Diffuse Lung Dis . 2008;25:64–67 .

37. 37 Lukens FJ , Machicao VI , Woodward TA , et al.   Esophageal sarcoidosis: an unusual diagnosis . J Clin Gastroenterol . 2002;34:54–56 . MEDLINE | CrossRef

38. 38 Friedman M , Ali MA , Borum ML . Gastric sarcoidosis: a case report and review of the literature . South Med J . 2007;100:301–303 . MEDLINE

39. 39 Fireman Z , Sternberg A , Yarchovsky Y , et al.   Multiple antral ulcers in gastric sarcoid . J Clin Gastroenterol . 1997;24:97–99 . MEDLINE | CrossRef

40. 40 Briley CA , Jackson DC , Johnsrude IS , et al.   Acute gastrointestinal hemorrhage of small-bowel origin . Radiology . 1980;136:317–319 . MEDLINE

41. 41 Sprague R , Harper P , McClain S , et al.   Disseminated gastrointestinal sarcoidosis. Case report and review of the literature . Gastroenterology . 1984;87:421–425 . Abstract | Full-Text PDF (736 KB)

42. 42 Godeau B , Farcet JP , Delchier JC , et al.   Protein-losing enteropathy in gastrointestinal sarcoidosis associated with malignant lymphoma . J Clin Gastroenterol . 1992;14:78–80 . MEDLINE | CrossRef

43. 43 MacRury SM , McQuaker G , Morton R , et al.   Sarcoidosis: association with small bowel disease and folate deficiency . J Clin Pathol . 1999;45:823–825 . MEDLINE | CrossRef

44. 44 Noël JM , Katona IM , Piñeiro-Carrero VM . Sarcoidosis resulting in duodenal obstruction in an adolescent . J Pediatr Gastroenterol Nutr . 1997;24:594–598 . MEDLINE | CrossRef

45. 45 Beniwal RS , Cummings OW , Cho WK . Symptomatic gastrointestinal sarcoidosis: case report and review of the literature . Dig Dis Sci . 2003;48:174–178 . MEDLINE | CrossRef

46. 46 Veitch AM , Badger I . Sarcoidosis presenting as colonic polyposis: report of a case . Dis Colon Rectum . 2004;47:937–939 . MEDLINE | CrossRef

47. 47 Ushiki A , Koizumi T , Kubo K , et al.   Colonic sarcoidosis presenting multiple submucosal tumor-like lesions . Intern Med . 2009;48:1813–1816 . CrossRef

48. 48 Akdogan M , Ulaş M , Kayhan B , et al.   Gastrointestinal sar-coidosis mimicking colonic cancer . Turk J Gastroenterol . 2008;19:136–138 .

49. 49 Munt PW . Sarcoidosis of the appendix presenting as ap-pendiceal perforation and abscess . Chest . 1974;66:295–297 . MEDLINE | CrossRef

50. 50 Bernaciak J , Spina JC , Curros ML , et al.   Case report: peritoneal sarcoidosis in an unusual location . Semin Respir Crit Care Med . 2002;23:597–600 . MEDLINE | CrossRef

51. 51 Uthman IW , Bizri AR , Khalifeh MJ . Peritoneal sarcoidosis . Semin Arthritis Rheum . 2002;31:353 . Full Text | Full-Text PDF (19 KB) | CrossRef

52. 52 Robertson LE , Cunningham JT . Primary peritoneal sar-coidosis . Dig Dis Sci . 1990;35:1545–1548 . MEDLINE | CrossRef

53. 53 Uthman IW , Bizri AR , Shabb NS , et al.   Peritoneal sar-coidosis: case report and review of the literature . Semin Arthritis Rheum . 1999;28:351–354 . Abstract | Full-Text PDF (1810 KB) | CrossRef

54. 54 Bourdillon L , Lanier-Gachon E , Stankovic K , et al.   Lofgren syndrome and peritoneal involvement by sarcoidosis: case report . Chest . 2007;132:310–312 . CrossRef

55. 55 Shukla M , Hassan MF , Toor V , et al.   Symptomatic pancreatic sarcoidosis. Case report and review of literature . JOP . 2007;8:770–774 . MEDLINE

56. 56 Romboli E , Campana D , Piscitelli L , et al.   Pancreatic involvement in systemic sarcoidosis. A case report . Dig Liver Dis . 2004;36:222–227 . Abstract | Full Text | Full-Text PDF (360 KB) | CrossRef

57. 57 Caceres M , Sabbaghian MS , Braud R , et al.   Pancreatic sar-coidosis: unusual presentation resembling a periampullary malignancy . Curr Surg . 2006;63:179–185 . Abstract | Full Text | Full-Text PDF (154 KB) | CrossRef

58. 58 Curran JF , Curran JF . Boeck's sarcoid of the pancreas . Surgery . 1950;28:574–578 . MEDLINE

59. 59 Baroni RH , Pedrosa I , Tavernaraki E , et al.   Pancreatic sar-coidosis: MRI features . J Magn Reson Imaging . 2004;20:889–893 . MEDLINE | CrossRef

60. 60 Lloyd-Davies RW , Forbes GB . Sarcoidosis of the gall bladder . Gastroenterology . 1965;49:287–290 .

61. 61 Kusielewicz D , Duchatelle V , Valeyre D , et al.   Obstructive jaundice caused by granulomatous stenosis of the extra-hepatic bile ducts in sarcoidosis . Gastroenterol Clin Biol . 1988;12:664–667 [In French] . MEDLINE

62. 62 Zia H , Zemon H , Brody F . Laparoscopic splenectomy for isolated sarcoidosis of the spleen . J Laparoendosc Adv Surg Tech A . 2005;15:160–162 . MEDLINE | CrossRef

63. 63 Rodríguez-García JL , Picazo J , Mira C , et al.   Systemic sarcoi-dosis with spleen involvement . Postgrad Med J . 2001;77:265 . MEDLINE | CrossRef

64. 64 Penna C , Deroide GA . Images in clinical medicine. Splenic sarcoidosis . N Engl J Med . 2003;349:e16 .

65. 65 Warshauer DM . Splenic sarcoidosis . Semin Ultrasound CT MR . 2007;28:21–27 . Abstract | Full Text | Full-Text PDF (6135 KB) | CrossRef

66. 66 Mohan A , Sood R , Shariff N , et al.   Sarcoidosis manifesting as massive splenomegaly: a rare occurrence . Am J Med Sci . 2004;328:170–172 . MEDLINE | CrossRef

a Department of Medicine, University of Connecticut Health Center, Farmington, USA

b Department of Anatomical Pathology, University of Connecticut Health Center, Farmington, USA

Corresponding Author InformationCorrespondence to: Dr George Y. Wu, Department of Medicine, Division of Gastroenterology Hepatology, University of Connecticut Health Center, Rm. AM-044, 263 Farmington Ave, Farmington, CT 06030, USA

PII: S0929-6646(10)60082-4

doi:10.1016/S0929-6646(10)60082-4


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