Volume 109, Issue 7, Pages 493-502 (July 2010)

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ABSTRACT

ABSTRACT + REFS

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Quality of Life in Taiwanese Breast Cancer Survivors With Breast-conserving Therapy

Received 7 April 2009; received in revised form 15 September 2009; accepted 19 November 2009.

Background/Purpose

Breast cancer is the most common female malignancy in Taiwan; however, quality of life (QOL) following breast cancer therapy remains rarely studied. The aim of the present study was to evaluate QOL among Taiwanese breast cancer patients with and without breast-conserving therapy.

Methods

A total of 130 women with breast cancer (37 with breast-conserving therapy and 93 with modified radical mastectomy) were enrolled between August, 2004 and December, 2007 in a single center. Patients who underwent breast-conserving therapy were younger, less likely to be married, had a higher educational level, and were at an earlier clinical stage than those who underwent modified radical mastectomy. The traditional Chinese version of the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-BR23 questionnaires were used as measuring instruments. Structural equation modeling with mean structural analysis, which evaluates configuration invariance and compares groups for latent functional/symptomatic factors, was constructed using a multi-indicators approach.

Results

Patients with breast-conserving therapy reported worse global QOL status and role function scores and higher symptomatic scores for fatigue, pain, dyspnea, insomnia, appetite loss, breast and arm problem subscales than those without conserving therapy. In addition, age, marital status, hormone manipulation and postoperative adjuvant therapy were significant confounders for QOL. Measurement invariance was ascertained and the same QOL construct could be applied to Taiwanese subjects with and without breast-conserving therapy.

Conclusion

Our study suggests that breast-conserving therapy might be associated with worse perceived QOL for Taiwanese breast cancer survivors.

Key Words: breast-conserving therapy , EORTC QLQ-BR23 , EORTC QLQ-C30 , quality of life , structural equation modeling

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Article Outline

• Abstract

• References

• Copyright

References

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a Division of General Surgery, Cathay General Hospital Sijhih Branch, Sijhih City, Taiwan

b School of Medicine, Fu Jen Catholic University, Sinjhuang, Taiwan

c Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

d Division of General Surgery, Department of Surgery, Cathay General Hospital, Taipei, Taiwan

e Department of Nursing, Cathay General Hospital, Taipei, Taiwan

f Division of Anesthesia, Cathay General Hospital Sijhih Branch, Sijhih City, Taiwan

g Preventive Medicine, National Taiwan University, Taipei, Taiwan

Correspondence to: Dr Wei-Chu Chie, Department of Public Health and Graduate Institute of Preventive Medicine, College of Public Health, National Taiwan University, Room 520, 17 Xuzhou Road, Taipei, 10055, Taiwan

PII: S0929-6646(10)60083-6

doi:10.1016/S0929-6646(10)60083-6

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